METHODS: Data were obtained from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort Study. This cross-sectional analysis of baseline data from men and women used the LUTS Tool to identify participants with and without UI, with and without OAB symptoms, and among those with OAB, those with urgency incontinence ( 00 OAB with UUI 00 ) versus without urgency incontinence ( 00 OAB without UUI 00 ). Metabolic factors assessed included: central obesity (age and race adjusted), body mass index (BMI), hypertension, dyslipidemia, and diabetes mellitus. Multivariable logistic regression was used to explore associations between metabolic factors and LUTS. RESULTS: The 920 patients (456 men, 464 women) had a mean age of 5914 years; 82% were White, 60% had central obesity, 43% had BMI 30, 65% had hypertension, 32% had dyslipidemia, and 17% had diabetes. Additionally, 67% reported UI, and 65% reported OAB. Central obesity was associated with the presence of any UI (odds ratio [OR]¼1.41, p¼0.044) and the presence of OAB (OR¼1.48, p¼0.014). There was no significant association between other meta- bolic factors examined and the presence of UI or OAB. Among patients with OAB (n¼595), there was no difference between those reporting OAB with UUI compared to OAB without UUI in any of the metabolic factors. Hypertension was associated with the presence of urinary fre- quency (OR¼1.46, p¼0.022). Dyslipidemia was associated with noc- turia, defined as waking to urinate at least twice a night (OR¼1.57, p¼0.004). CONCLUSIONS: We observed associations between both UI and OAB and central obesity, but not with other metabolic factors (hy- pertension, dyslipidemia, or diabetes) among men and women seeking treatment for LUTS. Central obesity was not associated with frequency or nocturia. Future studies are needed to further investigate the mechanistic links between OAB/UI and central obesity. Source of Funding: Funding provided by grants from NIH/ NIDDK MP27-10 HOW DOES DIABETES AFFECT VOIDING DYSFUNCTION? A MATCHED PAIRS STUDY Dina Manasherova*, Gen Li, Carrie M Aisen, Doreen E Chung, New York, NY INTRODUCTION AND OBJECTIVES: Diabetes mellitus (DM) remains a major health concern in the United States with an estimate of 9.4% of the population affected in 2015. Few studies have examined the relationship between DM and voiding dysfunction. It is theorized that DM leads to diabetic cystopathy, characterized by large capacity bladder (LCB), impaired sensation (IS), poor contractility, and high post- void residual volume (PVR). Our objective was to compare urodynamics studies (UDS) between DM and non-DM patients. METHODS: We retrospectively reviewed UDS of 1144 patients. 303 (26.5%) patients had DM and 841(73.5%) did not. We performed age matching of 303 DM with 303 non-DM patients; gender proportions were not significantly different. Presenting symptoms, UDS parameters and diagnoses were compared. We used Mann-Whitney test for continuous outcomes and t-test and Chi-squared test for binary out- comes with p0.05 for significance. RESULTS: Of the patients with DM, 91 (30%) had DM for >10 years. 100 patients (33%) had HgA1C above 6.5%. No significant dif- ference was found in complaints, such as frequency (p¼0.31), urgency (p¼0.80) and stress urinary incontinence (SUI) (p¼0.71) between two groups. On UDS, patients with DM did not show a significant difference in maximum flow rate (Qmax) (12.7812.01 ml/s DM vs 11.949.80 ml/ s non-DM, p¼0.36), detrusor pressure (Pdet) at Qmax (37.8628.55 cmH2O DM vs 37.7631.75 cmH2O non-DM, p¼0.97), and maximum Pdet (53.0846.65 cmH2O DM vs 50.1939.39 cmH2O non-DM, p¼0.428), but patients with DM had significantly higher volume at first urge (247.48178.60 ml DM vs 211.98134.74ml non-DM, p¼0.009). No differences were seen in SUI (p¼0.96), detrusor overactivity (63% in DM and non-DM, p¼0.9), and PVR (147.70212.12 ml DM vs 123.95185.36 ml non-DM, p¼0.13). DM patients had more LCB (54% DM vs 38% non-DM, p¼0.0043) and IS (46% DM vs 24% non-DM, p¼0.0001) compared to non-DM patients. CONCLUSIONS: This is one of the only studies to compare voiding dysfunction between patients with and without DM. Age-sample matching allowed to analyze the DM-specific effects on voiding dysfunction, showing that none of the complaints are significantly related to DM, yet patients with DM are diagnosed more often with LCB and IS, lending evidence for the phenomenon of diabetic cystopathy. Further studies are needed to evaluate the effect on treatment outcomes. Source of Funding: None MP27-11 OVERACTIVE BLADDER, URINARY INCONTINENCE AND DEPRESSION Antonella Giannantoni, Marilena Gubbiotti, Ettore Mearini, Pierfrancesco Maria Balducci, Jacopo Adolfo Rossi de Vermandois*, Perugia, Italy INTRODUCTION AND OBJECTIVES: The importance of af- fective disorders(e.g. depression and anxiety) in the aetiology of urinary incontinence (UI) and overactive bladder(OAB) has been greatly emphasized. Despite this growing interest, the exact nature of the as- sociation between OAB, UI and depression remains still unknown. We compared incontinent patients affected by depression to patients with lower urinary tract symptoms (LUTS) without depression seen at our incontinence clinic. METHODS: A total of 600 consecutive women with LUTS, all affering to a Urology Clinic were studied. After excluding patients with urologic conditions suggestive of outlet obstruction, 400 patients were classified into 2 Groups: Group 1, including 200 cases with LUTS and depression; Group 2 (control group) including patients affected by LUTS without depression. A clear diagnosis of depression was made by a psychiatrist from the results of the Self Rating Depression Scale (SRDS) questionnaire recorded by patients. Selected depressant pa- tients were only those assuming antidepressant drugs and in which the onset of depression preceded the emergence of UI. The following pa- rameters were recorded and compared between the two Groups: types and frequency of daily UI (urgency, stress or mixed UI) and of OAB symptoms, Incontinence Quality of Life Questionnaire (I-QoL), presence and severity of detrusor overactivity (DO) on urodynamics (first volume and maximum pressure of unhinibited detrusor contractions- UDC), types of pharmacological agents assumed for depression. RESULTS: Mean  SD age was 67.8  11.2 in Group 1 and 65.6  12.4 in Group 2. Mean  SD duration of urinary symptoms was 6.4  5.9 in Group 1 and 5.36  5.4 in Group 2. Mean  SD duration of depressive symptoms was 8.5  6.4. OAB symptoms, QoL and uro- dynamic parameters were significatly worse in patients with depression and LUTS (see Table). CONCLUSIONS: In the present study, the observed significant association between presence and severity of OAB symptoms and UI, reduced QoL and depression, suggests a causality between bladder dysfunction and the affective disorder, rather than a mere association. This association is consistent with a common neuropharmachological basis for incontinence and depression. e350 THE JOURNAL OF UROLOGY â Vol. 199, No. 4S, Supplement, Saturday, May 19, 2018