Z.U.M.J.Vol. 24; No.4 July.;2018 The Predictive Value Of Newly….. Alaa N., et al…. - 289- THE PREDICTIVE VALUE OF NEWLY DEFINED CHA 2 DS 2 -VASC-HSF SCORE FOR SEVERITY OF CORONARY ARTERY DISEASE IN NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION Mohamed Hassan , said Dwedar - Ashraf Al , Cekelly - Mostafa Al Montaser , shorbagy - Alaa Nabil Al Soliman Department of Cardiology, Faculty of medicine, Zagazig University, Egypt ABSTRACT Background: CHADS2 and CHA2DS2-VASc scores are widely used in clinical practice and include similar risk factors for the development of coronary artery disease (CAD). It is known that factors comprising the newly defined CHA2DS2-VASC-HSF score promote atherosclerosis and are associated with severity of CAD [1] . Aim: To investigate the association of CHA2DS2-VASc-HSF score with severity of Coronary Artery Disease as assessed by Syntax Score (SxS) in patients with Non ST Segment Elevation Myocardial Infarction. Subjects and methods: A total of 50 patients with NSTEMI (37 males and 13 females, their age ranged from 35 to 77 years old with a mean age of 57.8 years old) who underwent coronary angiography were included in our study. The patients were divided into 2 groups according to SxS score (SxS ≤22 and SxS < 22(. Results: This study showed a statistically significant positive correlation between CHA2DS2-VASC-HSF score and Syntax score I of patients. There is a statistically significant positive correlation between CHA2DS2-VASC- HSF score and serum cholesterol levels of patients. A statistically significant positive correlation was found between CHA2DS2-VASC-HSF score and serum LDL levels of patients. Our study also showed a statistically significant negative correlation between CHA2DS2-VASC-HSF score and ejection fraction (EF%) of patients. Conclusions: A newly defined CHA2DS2-VASC-HSF score predicts the severity of atherosclerosis in patients with NSTEMI. Keywords: CHA2DS2-VASC-HSF score, severity, syntax score, coronary artery disease, NSTEMI Corresponding author: Alaa Nabil Al-shorbagy, 01117170749, mellnart1990@gmail.com INTRODUCTION oronary artery disease (CAD) is the leading cause of morbidity and mortality in the present world. Risk factor assessment, prevention and treatment of CAD are an important aspect of present day research. Stable angina, often referred to as angina of effort, and its principal cause, reduction of the lumen of epicardial coronary arteries, have been recognized for >2 centuries [2] . Acute myocardial infarction (AMI), its clinical picture, and the importance of coronary thrombosis in its origin were described a century ago [3] . These 2 conditions, stable angina and AMI, although manifestations of the same underlying disease process, that is, coronary atherosclerosis, were initially considered to be quite distinct [4] . The MB fraction of creatine kinase (CK- MB) was considered to be the most sensitive and specific such biomarker [5] . Because serial determinations of CK-MB were not routinely obtained in patients with NSTE-ACS, NSTEMI was not excluded in many patients who were considered to have unstable angina (UA) [4] . Although CK-MB was superior to previously available enzymes, it lacked both optimal sensitivity and specificity [6] . The introduction by [7] of an assay for cardiac- specific troponin I (cTnI) and by [8] for cardiac- specific troponin T shortly thereafter provided 2 closely related biomarkers that were considerably more sensitive and specific than CK-MB [9] . CHADS2 score has been proven to be effective in the evaluation of the risk of stroke in patients with non-valvular atrial fibrillation. A high score indicates a greater risk of stroke. The score helps to plan further management of the non-valvular atrial fibrillation patient with respect to use of antiplatelets or anticoagulants. CHA2DS2-VASc score has recently replaced the traditional score as it has better stratification in low risk patients. In all past literature CHADS2 and CHA2DS2-VASc scores have been proven effective for assessing prognostic C