International Journal of Advances in Medicine | May 2020 | Vol 7 | Issue 5 Page 741 International Journal of Advances in Medicine Gupta G et al. Int J Adv Med. 2020 May;7(5):741-744 http://www.ijmedicine.com pISSN 2349-3925 | eISSN 2349-3933 Original Research Article Correlation between HbA1c level and LDL cholesterol level in ischemic stroke patients Gaurav Gupta, Mohammad Aquiqe*, Richa Giri, Shivendra Verma INTRODUCTION Stroke or cerebrovascular accident (CVA) is defined as an abrupt onset of a neurological deficit attributable to a focal vascular cause. Thus the definition of stroke is clinical, and laboratory studies including brain imaging are used to support the diagnosis. The focal vascular event may include cerebral infarction, intra-cerebral haemorrhage (ICH), and subarachnoid haemorrhage (SAH). 1 Acute ischemic stroke (AIS) occurs as a result of an event that limits or stops blood flow, including extra- cranial or intracranial thrombotic embolism, thrombosis in situ or relative hypo-perfusion. Affected regions with cerebral blood flow of lower than 10 mL/100 gm of tissue/min form the infarct core, and these cells are presumed to die within minutes of stroke onset. Zones of decreased or marginal perfusion (cerebral blood flow <25 mL/100g of tissue/min) are collectively called the ischemic penumbra. Tissue in the penumbra can remain viable for several hours because of marginal tissue perfusion; however, it is often consumed by progressive insults, and coalesces with the infarcted core, often within hours of the onset of the stroke. 2 On the cellular level, the ischemic neuron becomes depolarized as ATP is depleted and membrane ion- transport systems fail. Disruption of cellular metabolism also impairs normal sodium-potassium plasma membrane pumps, producing an intracellular increase in sodium, which in turns increases intracellular water content. This cellular swelling is referred to as cytotoxic oedema and occurs very early in cerebral ischemia. 3 ABSTRACT Background: Defects in insulin action and hyperglycemia could lead to Dyslipidemia in patients with diabetes. Methods: Cross sectional study carried out in patients presenting with ischemic stroke to medicine emergency unit of the LLRH Hospital from January 2018 to October 2019.Patient of age group 40-80 years The subjects in the present study were 450 patient comprised of 235 cases with ischemic stroke of age group of 40-80 years and 215 health y controls of age group of 40-80 years. Results: The correlation between these two variable as elicited from data obtained from study and, is significant (p<0.0001). The sensitivity of this correlation in the context of ischemic stroke is 75%, while the specificity is 60%. However, an impressive negative predictive value of 91% suggests a beneficial effect of normal or well controlled diabetes and Dyslipidemia. Conversely, a modest positive predictive value of 29% does not appear to help in utilizing this correlation as a measure of future likelihood of ischemic stroke. p value 0.00005 inference-highly significant. Conclusions: Study show statistically significant association (p < 0.001) of increased levels of HbA1c and LDL-C in patients of ischemic stroke. Keywords: Diabetes, Dyslipidemia, Infarct, Ischemia Department of Medicine, G. S. V. M. Medical College, Kanpur, Uttar Pradesh, India Received: 06 March 2020 Accepted: 30 March 2020 *Correspondence: Dr. Mohammad Aquiqe, E-mail: dr.akeek2013@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-3933.ijam20201608