materials Review Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges Rakesh K. Sindhu 1 , Agnieszka Najda 2, * , Prabhjot Kaur 1 , Muddaser Shah 3, * , Harmanpreet Singh 1 , Parneet Kaur 1 , Simona Cavalu 4 , Monika Jaroszuk-Sieroci ´ nska 5 and Md. Habibur Rahman 6,7, *   Citation: Sindhu, R.K.; Najda, A.; Kaur, P.; Shah, M.; Singh, H.; Kaur, P.; Cavalu, S.; Jaroszuk-Sieroci ´ nska, M.; Rahman, M.H. Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges. Materials 2021, 14, 5965. https://doi.org/10.3390/ ma14205965 Academic Editors: Jiawei Liu, Dongdong Wang and Rene Buchet Received: 18 August 2021 Accepted: 30 September 2021 Published: 11 October 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil- iations. Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1 Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India; rakesh.sindhu@chitkara.edu.in (R.K.S.); prbhjotkaur45@gmail.com (P.K.); harmanaulakh099@gmail.com (H.S.); parneetdhaliwal11@gmail.com (P.K.) 2 Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 50A Do´ swiadczalna St., 20-280 Lublin, Poland 3 Department of Botany, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan 4 Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania; simona.cavalu@gmail.com 5 Institute of Soil Science and Environment Shaping, University of Life Sciences in Lublin, 7 Leszczy ´ nskiego St., 20-069 Lublin, Poland; monika.jaroszuk@up.lublin.pl 6 Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh 7 Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea * Correspondence: agnieszka.najda@up.lublin.pl (A.N.); muddasershah@awkum.edu.pk (M.S.); pharmacisthabib@gmail.com (M.H.R.) Abstract: Studies from past years have observed various enzymes that are artificial, which are issued to mimic naturally occurring enzymes based on their function and structure. The nanozymes possess nanomaterials that resemble natural enzymes and are considered an innovative class. This innovative class has achieved a brilliant response from various developments and researchers owing to this unique property. In this regard, numerous nanomaterials are inspected as natural enzyme mimics for multiple types of applications, such as imaging, water treatment, therapeutics, and sensing. Nanozymes have nanomaterial properties occurring with an inheritance that provides a single substitute and multiple platforms. Nanozymes can be controlled remotely via stimuli including heat, light, magnetic field, and ultrasound. Collectively, these all can be used to increase the therapeutic as well as diagnostic efficacies. These nanozymes have major biomedical applications including cancer therapy and diagnosis, medical diagnostics, and bio sensing. We summarized and emphasized the latest progress of nanozymes, including their biomedical mechanisms and applications involving synergistic and remote control nanozymes. Finally, we cover the challenges and limitations of further improving therapeutic applications and provide a future direction for using engineered nanozymes with enhanced biomedical and diagnostic applications. Keywords: nanozymes; nanomaterials; artificial; cancer diagnosis; therapeutics; biomedical 1. Introduction Enzymes are considered natural biocatalysts which catalyze many biochemical reac- tions with good catalytic efficiency, biocompatibility, and substrate specificity. Recently, these reactions have been extensively used in various food industries and other biomedical applications. Their use in the agri-food industry promotes proper processing, storage activities and the functionalization of food products [1–6]. Enzymes play a significant role in enhancing the safety of food products [7]. Nanotechnology is believed to have a major part in advanced drug formulation, targeting a specific part of the body and controlled release of the drug. Nanotechnology is stated to communicate with the barrier of physical and organic sciences by putting forward nanospheres and structures in numerous scientific Materials 2021, 14, 5965. https://doi.org/10.3390/ma14205965 https://www.mdpi.com/journal/materials