_____________________________________________________________________________________________________ *Corresponding author: E-mail: n.omoregie@kingsuniversity.edu.ng; European Journal of Medicinal Plants 28(2): 1-7, 2019; Article no.EJMP.41692 ISSN: 2231-0894, NLM ID: 101583475 Total Protein, Bilirubin and AST Levels in Rat Models Treated with Ethanolic Extract of Eleusine coracana during Arsenic Trioxide Induced Hepatotoxicity Oyedotun M. Oyeleke 1,2 , Nosarieme O. Abey 1* , Babatunde J. Oso 1 and Nnenna C. Jackson 2 1 Department of Biochemistry, Kings University, Odeomu, Osun State, Nigeria. 2 Department of Biochemistry, Osun State University, Osogbo, Osun State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author OMO designed the study and wrote the protocol. Authors BJO and NJ managed the analyses of the study. Author NOA performed statistical analysis, managed the Literature search and wrote the first draft of the manuscript. All authors read and approved the final manuscript. Article Information DOI: 10.9734/EJMP/2019/v28i230131 Editor(s): (1) Dr. Sechene Stanley Gololo, Senior Lecturer, Department of Biochemistry, Sefako Makgatho Health Sciences University, South Africa. (2) Prof. Marcello Iriti, Professor of Plant Biology and Pathology, Department of Agricultural and Environmental Sciences, Milan State University, Italy. Reviewers: (1) Norma Aurea Rangel Vazquez Posgarde, Mexico. (2) Ioana Stanciu, University of Bucharest, Romania. (3) Noriah Bidin, Universiti Teknologi Malaysia, Malaysia. Complete Peer review History: http://www.sdiarticle3.com/review-history/41692 Received 02 August 2018 Accepted 16 October 2018 Published 19 June 2019 ABSTRACT Eleusine coracana is considered one of the most nutritious cereals. It has different names in local languages. It is known as Ragi in Telugu and Kannada/aariyam in Tamil, and Madua in Hindi and in Nigeria, it is known as Okababa in Yoruba, Dawa in Hausa, etc. This study sought to investigate the protective ability of ethanolic extracts of Eleusine coracana in Arsenic trioxide induced hepatotoxicity using rat models. Animals were grouped into four (4). Group A received only distilled water, in group B,C and D hepatotoxicity was induced using 5 mg/dl Arsenic Trioxide solution for 14 days, followed by treatment in group C and D daily with 200 mg and 500 mg per kg body weight respectively for 14 days, and changes in body weight and Liver Function parameters were Original Research Article