S1 Cu-Catalyzed Direct Diversification of 2-(2-Bromophenyl) Quinazolin-4(3H)-ones Through Orthogonal Reactivity Modulation Satadru Chatterjee #a , Ravuri Srinath #b , Suvankar Bera a , Krishnendu Khamaru, Afifa Rahman and Biswadip Banerji a, c * a Organic and Medicinal Chemistry Division, CSIR- Indian Institute of Chemical Biology (CSIR-IICB), Raja S.C. Mullick Road, Kolkata-700032 (India) b National Institute of Pharmaceutical Education and Research (NIPER-Kolkata), Chunilal Bhawan, Maniktala, Kolkata-700054 (India) c Academy of Scientific and Innovative Research (AcSIR), CSIR-IICB; 4 Raja S. C. Mullick Road, Kolkata, Country. India-700032; Fax: (+) 91 33 24735197, 91 33 24723967; Tel: (+) 91 33 24995709; E-mail: biswadip.banerji@gmail.com,biswadip@iicb.res.in Supporting Information Table of Contents 1 General Information --------------------------------------------------------------------------S2 2 General procedure for the synthesis of compounds 3a-3i----------------------------S2-S7 3 General procedure for the synthesis of compounds 4a-4l---------------------------S7-S15 4 General procedure for the synthesis of compounds 5a-5c-------------------------S15-S17 5 X-ray Crystallography Data------------------------------------------------------------S17-S20 6 DFT studies for compound 4a -------------------------------------------------------- S21 7 References -------------------------------------------------------------------------------- S22 8 1 H and 13 C NMR Spectra ----------------------------------------------------------------S23-S73