Neuroscience & Medicine, 2019, 10, 272-291 http://www.scirp.org/journal/nm ISSN Online: 2158-2947 ISSN Print: 2158-2912 DOI: 10.4236/nm.2019.103021 Sep. 24, 2019 272 Neuroscience & Medicine Blood Chemistry and Major Body Organ Induced-Toxicity by Locally-Made Traditional OMGKRP Karuho Poison in Wistar Albino Rats Samuel Kule Kyolo 1 , John Odda 2 , Aloysius Lubega 2 , Godfrey S. Bbosa 2* 1 Department of Pharmacy, Provincial Hospital of North Kivu, Goma, DR. Congo 2 Department of Pharmacology and Therapeutics, Makerere University College of Health Sciences, Kampala, Uganda Abstract OMGKRP is one of various Karuho poison mysteriously used by unscrupul- ous individuals to kill people during conflict and animals in Goma City, in DRC. The symptoms and signs of most cases are usually confused with many chronic diseases like tuberculosis and HIV/AIDS; with renal, hepatic and car- diac manifestations as well as blood chemistry changes. The study investi- gated the toxic effect of OMGKRP poison on blood chemistry, serum en- zymes and organ toxicity including the kidney, lung, liver and heart of Wistar albino rats. A laboratory-based experimental study was conducted. Fifty ani- mals in 5 groups each with 10 animals were dosed daily for 28 days with 1.0 mg, 5.0 mg, 20.0 mg and 5000.0 mg/Kg body weight of OMGKRP and normal saline as control group. International standard guidelines, OECD 407 and NIH 2011 were followed during the study period. The blood chemistry analy- sis, relative organ weight and histopathological changes in the kidney, lung, liver and heart were performed. The findings showed that OMGKRP was as- sociated with increased blood chemistry parameters including total proteins, creatinine, urea, K + levels, direct albumin levels, a decrease in Cl − levels and albumin levels. Histopathological findings showed an increased relative weight and tissue damages of the lung, kidney, liver and heart. Therefore, OMGKRP Karuho poison caused toxicity on blood chemistry, serum enzymes as well as histopathological changes in the lung, renal, hepatic and cardiac tissue dam- ages in Wistar albino rats. Keywords Blood Chemistry, Serum Enzymes, OMGKRP Karuho Poison, Organ Toxicity, Sub-Acute Toxicity How to cite this paper: Kyolo, S.K., Odda, J., Lubega, A. and Bbosa, G.S. (2019) Blood Chemistry and Major Body Organ In- duced-Toxicity by Locally-Made Tradition- al OMGKRP Karuho Poison in Wistar Albino Rats. Neuroscience & Medicine, 10, 272-291. https://doi.org/10.4236/nm.2019.103021 Received: August 10, 2019 Accepted: September 21, 2019 Published: September 24, 2019 Copyright © 2019 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access