Aishwarya Pande, Poonam Rai, Devanand Shetty. Nutrigenomics In Periodontics “A Hype Or A Hope” - An Overview. Int J Dentistry Oral Sci. 2021;08(02):1753-1756. 1753 OPEN ACCESS https://scidoc.org/IJDOS.php Nutrigenomics In Periodontics “A Hype Or A Hope” - An Overview Review Article Aishwarya Pande 1* , Poonam Rai 2 , Devanand Shetty 3 1 Post Graduate Student, Department of Periodontics and Oral Implantology, D Y Patil School of Dentistry, Navi Mumbai, India. 2 Professor, Department of Periodontics and Oral Implantology, D Y Patil School of Dentistry, Navi Mumbai, India. 3 Professor & Head of Department, Department of Periodontics and Oral Implantology, D Y Patil School of Dentistry, Navi Mumbai, India. International Journal of Dentistry and Oral Science (IJDOS) ISSN: 2377-8075 *Corresponding Author: Aishwarya Pande, Post Graduate Student, Department of Periodontics and Oral Implantology, D Y Patil School of Dentistry, Navi Mumbai. Tel: +91 90966 80130 Email Id: pande.aishwarya63966@gmail.com Received: December 02, 2020 Accepted: January 21, 2021 Published: February 27, 2021 Citation: Aishwarya Pande, Poonam Rai, Devanand Shetty. Nutrigenomics In Periodontics “A Hype Or A Hope” - An Overview. Int J Dentistry Oral Sci. 2021;08(02):1753-1756. doi: http://dx.doi.org/10.19070/2377-8075-21000346 Copyright: Aishwarya Pande © 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Introduction Periodontitis represents a multifactorial group of infectious dis- eases that lead to destruction of the supporting tissues of the teeth. Prolonged release of neutrophils, proteolytic enzymes, proinfammatory mediators and reactive oxygen species occurs, when infammatory response fails to remove the causative patho- gens, which in turn leads to destruction of periodontal attach- ment. The importance of successful management and treatment of periodontitis has gained more attention in the recent years with the recognition that periodontitis is a risk factor for a number of important systemic diseases, which include cardiovascular dis- ease, diabetes and rheumatoid arthritis. Investigating the relation amongst nutrients and periodontal disease has been important to understand the potential role of dietary modifcation in the pre- vention and treatment of periodontal disease. All About Nutrigenomics Nutrigenomics is an emerging feld of science and technology unrevealing inter-relationships between nutrients and human genome using modern tools such as transcriptomics, metabo- lomics, epigenomics and proteomics. The term “NUTRI” refers to Nutrition and “GENOMICS” is referred to as the process by which all genes present in the genome of a given species can be mapped, sequenced and characterized [1] Nutrigenomics is also called as nutritional genomics which refers to both the study of, on how diet affects genes and how genes affect diet. The term “nutrigenomics” was frst described in 2001 from Pelegrin (2001). In 2004, NuGo (European Nutrigenomics Organization) was started and funded until June 2010 [2]. Nutrigenomics aims to identify the genes that infuence the risk of diet-related diseases on a genome-wide scale, and to understand the mechanisms that underlie these genetic predispositions. It is extremely likely that interactions between genotype and diet are important in deter- mining the risk of the most common complex diseases, including periodontal disease. Future Of Nutrigenomics: Transcriptomics, Prot- eomics Or Metabolomics? Genomics tools can be used in two different, but complementary, strategies in molecular nutrition research: specifc genes and pro- Abstract The role that diet plays in the development and progression of dental caries has been well documented, but the importance of nutrition as a predisposing factor for the development of periodontal diseases is still under research. The possible protec- tive role of nutrients and genetics on periodontal tissue has led to an increased interest to establish the association between nutrition and periodontal disease. Nutrition infuences growth, development and metabolic activities of periodontium, where as the pathogenesis of periodontitis is regulated by an imbalance between microbes and the immune system which in turn is infuenced by various genetic factors. This review throws a ray of hope and summarizes the evidence of nutritional impact on periodontitis and daily nutritional regime for periodontal disease prevention. Keywords: Nutrigenomics; Periodontitis; Metabolomics; Antioxidants.