DMD #48918 1 In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC USA (MJR, PMS, GTG, JEH, LOW, KAH, JWP) Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, UK (HT, JDC) Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (EK) DMD Fast Forward. Published on November 6, 2012 as doi:10.1124/dmd.112.048918 Copyright 2012 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on November 6, 2012 as DOI: 10.1124/dmd.112.048918 at ASPET Journals on October 14, 2021 dmd.aspetjournals.org Downloaded from