Neutrophil adhesion in brain capillaries contributes to cortical blood flow decreases and impaired memory function in a mouse model of Alzheimer’s disease Authors: Jean C. Cruz Hernández 1, *, Oliver Bracko 1, *, Calvin J. Kersbergen 1 , Victorine Muse 1 , Mohammad Haft-Javaherian 1 , Maxime Berg 2 , Laibaik Park 3 , Lindsay K. Vinarcsik 1 , Iryna Ivasyk 1 , Yiming Kang 1 , Marta Cortes-Canteli 4,5 , Myriam Peyrounette 2 , Vincent Doyeux 2 , Amy Smith 2 , Joan Zhou 1 , Gabriel Otte 1 , Jeffrey D. Beverly 1 , Elizabeth Davenport 1 , Yohan Davit 2 , Sidney Strickland 4 , Costantino Iadecola 3 , Sylvie Lorthois 1,2 , Nozomi Nishimura 1,+ , Chris B. Schaffer 1,+ Affiliations: 1 Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA 2 Institut de Mécanique des Fluides de Toulouse (IMFT), Université de Toulouse, CNRS, INPT, UPS, Toulouse, France 3 Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA 4 Patricia and John Rosenwald Laboratory for Neurobiology and Genetics, The Rockefeller University, New York, NY, USA 5 Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain *These authors contributed equally + These authors jointly guided the research + Corresponding author e-mail addresses: nn62@cornell.edu and cs385@cornell.edu . CC-BY-NC 4.0 International license was not certified by peer review) is the author/funder. It is made available under a The copyright holder for this preprint (which this version posted November 29, 2017. . https://doi.org/10.1101/226886 doi: bioRxiv preprint