Review Article ARTABOTRYS HEXAPETALUS (L. F.) BHANDARI: A PLANT WITH ENORMOUS BIOMEDICAL POTENTIAL ABHIJEET V. PURI Department of Pharmacognosy, St. John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Palghar, 401404, Maharashtra, India Email: avpuri@rediffmail.com Received: 06 Apr 2020, Revised and Accepted: 04 May 2020 ABSTRACT This review is intended to investigate the published report regarding phytochemical, ethnomedicinal, and pharmacological activities and put forth the therapeutic potential of Artabotrys hexapetalus (L. f.) Bhandari. (A. hexapetalus). It belongs to the family Annonaceae, one of the therapeutically important plants, broadly distributed throughout the world. An extensive review of the literature available in various recognized databases including logical writing and scientific literature, search engines such as Springerlink, ScienceDirect, SciFinder, PubMed, Scopus, Google Scholar, and BioMed Central as well as relevant books, websites, scientific publications, and dissertations were utilized as a source of information that provided an up-to-date review. Phytochemical profiling of these species revealed the presence of some imperative phytochemicals alkaloids, terpenoids, anthraquinones, butyrolactones, flavonoids, neolignans, phenolic compounds, and leucoanthocyanins as the basis of its valuable therapeutic properties. The other imperative phytoconstituents which contribute to the therapeutic properties are isoamericanin A, isoamericanol, americanin, artabotricinol and artabotriol, β-unsaturated-β-butyrolactones, arapetaloside taxifolin, apigenin-7-O-apiosylglucoside, glucoluteolin, and artabotrine. The pharmacological activities exhibited by Artabotrys hexapetalus as antimicrobial, antileishmanial, antioxidant, antifungal, antifertility, and anthelmintic properties are attributed to the presence of valuable bioactive phytoconstituents. Considering these facts an effort was made to present a comprehensive review enlightening the taxonomical, phytochemical, and pharmacological activities of plant Artabotrys hexapetalus. Future research can be directed to an extensive investigation about phytochemistry, clinical trials, pharmacokinetics, and acquiring safety data to add new dimensions to the therapeutic utilization of Artabotrys hexapetalus and other Artabotrys species. Keywords: Artabotrys hexapetalus, Annonaceae, Pharmacological, Phytochemicals © 2020 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) DOI: http://dx.doi.org/10.22159/ijpps.2020v12i6.37778. Journal homepage: https://innovareacademics.in/journals/index.php/ijpps INTRODUCTION Artabotrys is a genus of woody trees, shrubs, and vines comprising about 130 genera and 2,300 species, which is distributed mainly in tropical and subtropical regions of the world, especially tropical Africa and Eastern Asia and the Indomalayan region [1, 2]. Plants of Artabotrys genus are climbing herbs bearing recurved hooks borne on lateral branches and scandent shrubs are one of the largest genera of the custard-apple family [3]. Artabotrys hexapetalus (L. f.) (A. hexapetalus) Bhandari generally described as a folk drug that has a wide range of medicinal uses belonging to family Annonaceae. The family includes trees, shrubs, and lianas, found in almost all vegetation types. It is generally considered to be a natural family and one of the six members of Magnoliales [4]. It is an ornamental, medium-sized woody climber that produces aromatic flowers with fragrance. A. hexapetalus is native to India and widely distributed in the southern part of China, and is used in traditional Chinese medicine for the treatment of malaria [5]. It is a medium-sized climbing shrub, largely cultivated in India. Leaves are oblong, lanceolate, and glabrous. Flowers solitary or paired, often fragrant, usually on woody, hooked recurved branches (Peduncles) [6]. It is widely distributed throughout the southern part of China and also in the southern part of Asia. As a Chinese traditional folk medicine, its roots and fruits are used for treating malaria and scrofula, respectively [7]. The flower is acrid, bitter; useful in vomiting, diseases of the blood and the heart, leucoderma, headache. A decoction of leaves is given for cholera. Phytochemically it contains alkaloids, anthraquinones, butyrolactones, flavonoids, neolignans, phenolic compounds, leucoanthocyanins, terpenoids, and volatile oils [8-10]. Many phytochemicals in the form of flavonoids of A. hexapetalus possibly be modified or used as “lead” for developing more effective drug molecules. Hence, extensive pharmacological and phytochemical screening, together with the pharmacokinetic and toxicological assay can be aimed at future investigations. Hence an attempt is made to highlight selected phytochemical and biomedical potentials of A. hexapetalus species in this review. Introduction to Artabotrys hexapetalus (L. f.) Bhandari Taxonomical classification [11] Domain: Eukaryota Kingdom: Plantae Subkingdom: Tracheophytes Division: Magnoliophyta Subphylum: Angiosperms Class: Magnoliopsida–Dicotyledons Subclass: Magnoliidae Order: Magnoliales Family: Annonaceae SubFamily: Annonoideae Genus: Artabotrys Species: Artabotrys hexapetalus Common Name: Ylang-Ylang, Hari Chafa Vernacular names [12] Sanskrit: Harachampaka. Tamil: Manoranjidam. Telugu: Manoranjidamu. Marathi: Vilayati Champa. Genus: Artabotrys Species: Hexapetalus International Journal of Pharmacy and Pharmaceutical Sciences Print ISSN: 2656-0097 | Online ISSN: 0975-1491 Vol 12, Issue 6, 2020