Synthesis of optically active α-trifluoromethylamines by rearrangement of β-amino-α-trifluoromethyl alcohols Z. Neouchy, a D. Gomez Pardo* a and J. Cossy* a a Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI Paris/CNRS/PSL Research University, 10 rue Vauquelin, Paris 75231 Cedex 05, France * E-mail: domingo.gomez-pardo@espci.fr * E-mail: janine.cossy@espci.fr Supporting Information Table of contents: General information…………………………………………………………………………...S-2 1. Preparation of the starting material………………………………………………..S-3 a. Swern oxidation…………………………………………………………………………..S-3 b. Trifluoromethylation reaction……………………………………………………..S-5 2. Treatment with DAST………………………………………………………………….....S-12 3. Rearrangement of β-amino-α-trifluoromethyl alcohols ……………......S-15 a. Synthesis of β-trifluoromethyl-β-aminoalcohol…………………………..S-16 b. Synthesis of α-trifluoromethylamines…………………………………………S-22 4. Application of α-trifluoromethylamines ……………………..……………..….S-32 5. Copies of the 1 H, 13 C NMR and 19 F spectra……………………..……………...S-34 S-1