International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.5, No.3, pp 1271-1280, July-Sept 2013 Effect Of Embellica Officinalis On Scopolamine And High Fat Diet Induced Memory Loss Supriyo Saha 1 *, Ashish Dimri 1 , Arun Chaudhary 2 , Sumit Durgapal 1 , Neha Joshi 3 1 *Himalayn Institute Of Pharmacy And Research, Atakfarm Rajawala, Dehradun-248001, Uttarakhand, India. 2 Shri Guru Ramrai Institute Of Technology And Science, Patel Nagar, Dehradun-248001, Uttarakhand, India. 3 Kumaon University, Bhimtal Campus, Nainital-263001, India. *Corres.author: supriyo9@gmail.com Mobile no: 7895424583 Abstract: Objective: To study the effect of Amla on High fat Diet induced memory loss as well as the Scopolamine induced memory loss on animals and checked the effect of Amla in case of disruption in the cholinergic transmission and Piracetam used as a standard substance for inducing memory power. Materials and Methods: This prospective study was carried out the Morris Water Maze and Elevated Plus Maze technique and different types of experimental protocol was generated based upon the High Fat Diet induced memory loss. Also checked the blood glucose and blood cholesterol level which was the most important parameter in case of obese patients. Results: In this study, scopolamine and high fat diet induced animals group showed an increase in ELT during the acquisition trials conducted from day 1 to day 4 where as groups treated with Amla showed a decrease in the ELT during the acquisition trials. High fat diet and scopolamine treated groups reduced the time spent in target quadrant (Q4) where as Amla treated groups showed an increase in the time spent in target quadrant (Q4). High fat diet was feed to animals for 3 months and that showed an increase in the cholesterol levels whereas the groups treated with Amla showed a significant decrease in the cholesterol level which ultimately stops the neuronal damage and neurotransmission is increased. Keywords: Embellica Officinalis ,Scopolamine ,High Fat Diet Induced Memory Loss. Introduction Hypercholesterolemia is a basic risk factor for inducing Alzeihmer’s disease due to the deposition o f amyloidal plaques in the cerebral cortex, mainly the amyloid-β peptide (Aβ1–40). These peptides are mainly inhibiting the neurotransmission of cholinergic system 1,2 . While growing evidence has shown that synaptic and cognitive dysfunction in AD is associated with intraneuronal accumulation of Aβ, the relationships between hypercholesterolemia 3 memory impairment, and intraneuronal Aβ remains unclear 4 . Embellica officianlis is reported to reduce the cholesterol deposition in rats as well as initiates the suppression of cholinergic system by decreasing the formation of neurofibrillary tangles and brain cholinesterase activity 5 . Excess cholesterol has