Accepted Manuscript GRADE Guidelines: 22. The GRADE approach for tests and strategies - from test accuracy to patient important outcomes and recommendations Holger J. Schünemann, Reem A. Mustafa, Jan Brozek, Nancy Santesso, Patrick M. Bossuyt, Karen R. Steingart, Mariska Leeflang, Stefan Lange, Tommaso Trenti, Miranda Langendam, Rob Scholten, Lotty Hooft, Mohammad Hassan Murad, Roman Jaeschke, Anne Rutjes, Jasvinder Singh, Mark Helfand, Paul Glasziou, Ingrid Arévalo Rodriguez, Elie A. Akl, Jonathan J. Deeks, Gordon H. Guyatt, GRADE Working Group PII: S0895-4356(17)31095-8 DOI: https://doi.org/10.1016/j.jclinepi.2019.02.003 Reference: JCE 9824 To appear in: Journal of Clinical Epidemiology Received Date: 11 December 2017 Revised Date: 14 November 2018 Accepted Date: 4 February 2019 Please cite this article as: Schünemann HJ, Mustafa RA, Brozek J, Santesso N, Bossuyt PM, Steingart KR, Leeflang M, Lange S, Trenti T, Langendam M, Scholten R, Hooft L, Murad MH, Jaeschke R, Rutjes A, Singh J, Helfand M, Glasziou P, Rodriguez IA, Akl EA, Deeks JJ, Guyatt GH, GRADE Working Group, GRADE Guidelines: 22. The GRADE approach for tests and strategies - from test accuracy to patient important outcomes and recommendations, Journal of Clinical Epidemiology (2019), doi: https:// doi.org/10.1016/j.jclinepi.2019.02.003. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.