IJPRD, 2011; Vol 3(10): December 2011 (80 - 87) International Standard Serial Number 0974 – 9446 Available online on www.ijprd.com 80 ---------------------------------------------------------------------------------------------------------------------------------------------------------------- FORMULATION, EVALUATION AND DEVELOPMENT OF BILAYER TABLET Kiran musle 1* , S.A Payghan, Dr. J.I.Disuza 1 PG Department Of Pharmaceutics, Tatyasaheb Kore College Of Pharmacy, Warnanagar, Kolhapur. ABSTRACT Bilayer tablet of diclofenac sodium and paracetamol was formulated with diclofenac as sustained release formulation. In the same sustained release layer of diclofenac sodium, an immediate layer of paracetamol was optimized separately and then constituted in bilayer tablet using the amount of polyethylene glycol, microcrystalline cellulose and crospovidone as independent variables for fabricating paracetamol tablets. Diclofenac sodium tablets were prepared using hydroxypropyl methylcellulose as a matrixing agent. Effect of these polymers concentration and different diluents were studied and was evaluated by dissolution studies of prepared bilayer formulations along with friability, hardness, content uniformity Correspondence to Author Kiran Musle PG Department Of Pharmaceutics, Tatyasaheb Kore College Of Pharmacy, Warnanagar, Kolhapur. Email kiranmusle87@gmail.com Key Words Bi-layer tablet, diclofenac sodium, paracetamol , test batch study