Corresponding author: Bita Sepehri Department of Gastroenterology and hepatology, Tabriz University of Medical Sciences, Tabriz, Iran sepehribrr@yahoo.com Received: 2014-01-15| Accepted: 2014-02-06| Published: 2014-02-20 DOI: 10.7575/aiac.abcmed.14.02.02.20 Copyright © Australian International Academic Centre, Australia 105 | P a g e Case report Advances in Bioscience & Clinical Medicine ISSN: 2203-1413 Vol.02 No.02 Duodenal Lipomatosis: A Case with Postprandial Dyspepsia Bita Sepehri 1* , Shahriar Hashemzadeh 2 , Keivan Kashy Zonouzy 2 , Mehdi Haghi 3 1.Department of Gastroenterology and hepatology, Tabriz University of Medical Sciences, Tabriz, Iran 2.Department of surgery, Tabriz University of Medical Sciences, Tabriz, Iran 3.Department of Genetics, Tabriz University of Medical Sciences, Tabriz, Iran Introduction Lipomas could be detected as benign mesenchymal tumors in all organs while they are rare in gastrointestinal tract (1). They constitute 5-6% of gastrointestinal (GI) tumors (1). Case presentation: Our patient was a 28 year old man that presented with dyspeptic symptoms such as early satiety, postprandial epigastric discomfort, nausea and occasional vomiting. He had no family history of GI Cancers. He had received multiple therapeutic regimens, but had no improvement in his symptoms. An upper GI endoscopy was performed revealing multiple smooth, yellow shadowed submucosal masses at different sizes, with positive pillow sign (in forceps examination) in second part of duodenum. Endoscope passed with difficulty from D1 to D2. Biopsies were obtained. With probable diagnosis of duodenal lipomatosis, an abdominal spiral CT- Scan was performed that showed multiple lipoma of duodenum (figure 1). Due to refractory symptoms, surgical treatment was planned and longitudinal duodenotomy, gastro-jejenostomy and biopsy sampling were performed. In laparatomic exploration, lipomas were limited to second Abstract Lipomas are benign mesenchymal tumors and constitute 5-6% of gastrointestinal tumors. They are generally asymptomatic and the occurrence of symptoms is related to the location and size of tumor. We present a 28 year old man with refractory dyspepsia for 18 months. In upper GI endoscopy multiple smooth submucosal masses with positive pillow sign were detected in second part of duodenum. Diagnosis was confirmed with CT-Scan.