Niaz Hussain Keerio et al., Int. J. Res. Pharm. Sci., 2021, 12(4), 2325-2329 OėĎČĎēĆđ AėęĎĈđĊ IēęĊėēĆęĎĔēĆđ JĔĚėēĆđ Ĕċ RĊĘĊĆėĈč Ďē PčĆėĒĆĈĊĚęĎĈĆđ SĈĎĊēĈĊĘ Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps Result of high Fibular Osteotomy (HFO) in Osteoarthritis knee Ajmal Khan Silro 1 , Muhammad Faraz Jokhio 2 , Mohsin Aijaz Soomro 3 , Raheel Akbar Baloch 4 , Niaz Hussain Keerio *5 , Najeeb Ur Rehman 6 , Syed Shahid Noor 7 1 Dibba Hospital, Fujairah, United Arab Emirates 2 Liaquat University of Medical and Health Science, Jamshoro, Sindh, Pakistan 3 Suleman Roshan Medical Collage, Tando Adam, Sanghar, Pakistan 4 Liaquat University Hospital, Hyderabad, Sindh, Pakistan 5 Muhammad Medical College and Hospital, Mirpurkhas, Sindh, Pakistan 6 Peoples University of health and Sciences for Women, Nawabshah, Sindh, Pakistan 7 Department of Orthopedic, Liaquat National Hospital And Medical College Karachi, Sindh, Pakistan Article History: Received on: 11 Jul 2021 Revised on: 15 Aug 2021 Accepted on: 23 Aug 2021 Keywords: high ϐibular osteotomy, osteoarthritis, knee, varus deformity, orthopedic, mesenchymal cell induced chondrogenesis AćĘęėĆĈę To assess the effectiveness of high ϐibular osteotomy (HFO) in improving func- tion and reducing pain among patients diagnosed with osteoarthritis knee admitted in the orthopedic department of Dibba Hospital Fujairah, United Arab Emirates. This is a descriptive, correlational cross-sectional study design. The study was conducted at the Orthopedic department Dibba Hos- pital Fujairah, United Arab Emirates, during the period from March 2019 to March 2020. All patients had knee osteoarthritis and were managed using HFO. All patients were adults and older than 18 years of age. Data was ana- lyzed using the SPSS program. Ethical approval was gained from the hospi- tal as well as from patients. The mean age of the patients was 32.5 ± 8.3 years. The study included 100 participants, among them, 28 were females, and 72 were males. There was a statistically signiϐicant relationship between knee injury and osteoarthritis outcome score and Lysholm. Also, knee x- rays images demonstrated clinical improvements among most of the patients. According to previous results, HFO and mesenchymal cell induced chon- drogenesis (MCIC)should be considered for treating of medial compartment osteoarthritis, especially in patients with varus deformity. * Corresponding Author Name: Niaz Hussain Keerio Phone: 00923333008501 Email: niaz_h@hotmail.com ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v12i4.4861 Production and Hosted by Pharmascope.org © 2021 | All rights reserved. INTRODUCTION Osteoarthritis is a common degenerative joint dis- ease. It affects mainly large body joints, espe- cially the knee joint. It causes movement limitation and severe pain (Naudie et al., 1999). It also dis- rupts the daily living and affects the patients’ qual- ity of life. There are various established treatments for this condition. High tibial osteotomy (HTO) is considered a main technique for this condition. Also, uni-compartmental knee arthroplasty (UKA) is used to manage the symptoms. These methods are used for osteoarthritis of the medial aspect of the knee joint (Dettoni et al., 2010). Since there are many post-surgical complications, arthroplasty procedures are now declining while preservative joint procedures are becoming more used (Spahn et al., 2013). This is noticed more among younger, active patients (Ryu et al., 2018). It is noticed that patients aged younger than 60 years are per- © International Journal of Research in Pharmaceutical Sciences 2325