ABSTRACT The study was designed to show the activity of crude alkaloids against the toxicity of E. granulosus. In this study, a total of 20 adult albino male rats were used and divided randomly to following groups (each group consist 5 rats); control group received ad libidium, positive group injected with 2,5 X 10 3 of E. granulosus protoscolices third group injected with protoscolices and treated with 0.25 mg/ml crude alkaloids, fourth group injected with protoscolices and treated with 0.25 mg/mL crude alkaloids. The results show high Scavenging activity of crude alkaloids extracts reaches 88.6%. Otherwise, The results show a highly signifcant increased (p < 0.05) in levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) in the group injected with protoscolices compared with the control group. Oxidative stress factors in the group injected with protoscolices show signifcant increased (p < 0.05) in levels of malonedialdehyied (MDA) and signifcantly decreased (p < 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used crude alkaloids with E. granulosus, the results showed non-signifcant changes (p < 0.05) in liver functions and MDA, GSH and catalase also showed non-signifcant changes (p < 0.05) compared with the control group. It was concluded that crude alkaloids has been a potential role against the toxicity of Echinococcus granulosus in male rats. Keywords: Catalase, Crude alkaloids, Echinococcus granulosus, Glutathione (GSH), Liver function, Malonedialdehyied (MDA). International Journal of Drug Delivery Technology (2019); DOI: 10.25258/ijddt.v9i3.11 How to cite this article: Ali, A.A. and Saleh, A.H. (2019). Potential activity of crude alkaloids against Echinococcus granulosus in adult albino male rats. International Journal of Drug Delivery Technology, 39(3): 9-12. Source of support: Nil Confict of interest: None Potential Activity of Crude Alkaloids against Echinococcus Granulosus in Adult Albino Male Rats Abeer A. Ali 1 , Ahmed H Saleh 2 1 Technical college of Kirkuk/North Technical University/Iraq 2 Medical Analysis department/ Al-Qalam College /Kirkuk/Iraq Received: 07th July, 19; Revised: 13th August, 19, Accepted: 08th September, 19; Available Online: 12th September, 2019 INTRODUCTION Hydatid cyst is a potential zoonotic disease of man and animals, caused by the metacestode of the dog tapeworm Echinococcus granulosus. 1 The adult form of the parasite lives in the intestine of canids as defnitive hosts. Humans and herbivore animals, as intermediate hosts, can be infected by ingesting the parasite’s eggs. Hydatid cyst is an important debilitating disease in humans, which often afects vital organs such as liver and lungs. 2-3 E. granulosus (s.l.) is found throughout the world, and canids are the defnitive host. Hydatid cysts may develop in the lungs, liver, brain, or other internal organs of intermediate hosts. 4 Rosmarinus ofcinalis L. is a medicinal plant that belongs to the Lamiaceae family and is commonly known as rosemary. 5 Many compounds have been isolated from Genista microcephala and Rosmarinus ofcinalis, including glycoside, flavones, alkaloids, turbines, saponins. 6 Alkaloids are naturally occurring compounds containing carbon, hydrogen, nitrogen, and usually oxygen and are primarily found in plants, especially in certain fowering plants. 7 The parts of a plant as stems, leaves, and roots are used in the treatment of RESEARCH ARTICLE several diseases; they act as antibacterial, antifungal, antiviral, anthelmintic, anti-infammatory, antioxidant, antidiabetic, antidiarrheal agent. 8 MATERIALS AND METHODS Animal model In this study, twenty adult male albino rats (wt 200-250 gm with age 4–6 months) obtained from Science college/ Tikrit University and kept on standard pellet diet for two weeks to ensure it’s normal and there isn’t any infection. Alkaloid extract Alkaloid extraction from R. officinalis leaves was done according to. 9 10 gm of dried and milled leaves were extracted in Soxhlet extractor for 24 hours at 40°C with 200ml of ethanol as a solvent, then it was evaporated at 50°C by a rotary evaporator. The dried extract was dissolved in 5 mL of 80% ethanol, 30mL of sulfuric acid was added, then it was dried in an electric oven to removed ethanol. The acidic extract was adjusted to pH = 9 using a 10% ammonium hydroxide solution. *Author for Correspondence: ahmedeagle72@gmail.com