33 Acta Pharmaceutica Sciencia. Vol. 57 No. 1, 2019 Acta Pharm. Sci. Vol 57 No: 1. 2019 DOI: 10.23893/1307-2080.APS.05703 Enhanced Solubility and Drug Release of Ketoprofen Using Lyophilized Bovine Serum Albumin Solid Dispersion Meenakshi Bhatia 1* , Rupa Devi 1 1 Guru Jambheshwar University of Science and Technology, Pharmaceutical Sciences, Hisar, India INTRODUCTION Biopharmaceutical classification system (BCS) divided the active pharmaceu- tical ingredient into four classes (I, II, III, IV) based on their solubility in water and membrane permeability. In recent years class II drugs (having low solu- bility & high permeability) have appeared oft times as candidate compound for development in drug discovery stage 1 . Various techniques including cyclo- dextrins complexes 2 , nanoparticle technology 3 , self emulsifying drug deliv- ABSTRACT Solid dispersions have been proved to be an effective method for the improvement of solubility and bioavailability of poorly water-soluble drugs. The study was de- signed to demonstrate the potential of ketoprofen loaded BSA solid dispersions on the solubility & in-vitro release of ketoprofen. Ketoprofen-BSA solid dispersions were prepared by the freeze-drying method. A 2-factor, 3-level central composite experimental design was used to study the effect of varying concentration of BSA and ketoprofen on drug solubility & in-vitro drug release. The combined effect of concentration of BSA & ketoprofen on % release and solu- bility exhibited a linear relationship between independent and dependent varia- bles, suggesting that higher level of BSA & ketoprofen favours the expedited release and solubility. Bovine serum albumin may be explored as a carrier for the preparation of solid dispersion for the enhancement of solubility and in-vitro drug release of BCS class II drug ketoprofen. Keywords: Bovine serum albumin, Ketoprofen, Solid dispersion, Lyophilization. *Corresponding author: Meenakshi Bhatia, e-mail: meenaxibhatia@gmail.com (Received 08 September 2018, accepted 19 October 2018)