International Journal of Advances in Medicine | November-December 2019 | Vol 6 | Issue 6 Page 1855 International Journal of Advances in Medicine Ghosh S et al. Int J Adv Med. 2019 Dec;6(6):1855-1858 http://www.ijmedicine.com pISSN 2349-3925 | eISSN 2349-3933 Original Research Article The impact of intravenous thrombolysis in acute ischemic stroke in National Medical College, Kolkata: initial experience Saikat Ghosh 1 , Manoj Kr. Mahata 2 *, Sarbajit Das 3 , K. C. Ghosh 3 , R. Bhattacharya 3 , G. P. Mondal 3 , Sumit Deb 3 INTRODUCTION Stroke is one of the most common causes of morbidity, mortality, in developed as well as in developing countries. WHO defined stroke as “rapidly developed clinical signs of focal disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than vascular origin”. In 2008, the estimated deaths worldwide due to cerebrovascular disease was 6.1 million, equivalent to 10.8% of all deaths worldwide. In India, the prevalence of stroke is less compared to that of developed countries but the proportion of stroke in young population is significantly more in India than that of in developed countries. In India, the prevalence of stroke is about 1.54 per 1000 population. The total number of stroke cases estimated in the year 2004 were about 9.3 million with about 0.63 million deaths. Intravenous (IV) thrombolysis with Recombinant Tissue Plasminogen Activator (r-TPA) has assumed vital importance in the successful treatment of acute ischemic stroke. Conventionally, alteplase infusion has proved to be efficacious in improving the functional outcomes when given within 4.5 h (h) of the stroke onset. 1,2 Tenecteplase can also be used in AIS within 3 hours of stroke onset. Present study was conducted with the objective to study clinical profile of patients with acute ischemic stroke receiving intravenous thrombolysis (r-TPA) and to measure the outcome of thrombolysis. METHODS This study is a retrospective analysis of 54 patients who underwent thrombolysis for acute ischemic stroke within the period of 13 th May 2016 to 12 th May 2017. Study design and subjects was all the acute ischemic stroke patients were assessed by the stroke on call resident in medical emergency on a priority basis. Those ABSTRACT Background: Acute ischemic stroke is a potentially treatable condition, if left untreated, lead to mortality and morbidity. This study was conducted to study clinical profile of patients with acute ischemic stroke receiving intravenous thrombolysis (r-TPA-alteplase) and to measure the outcome of thrombolysis. Methods: Retrospective observational study of 54 patients who underwent thrombolysis for acute ischemic stroke at National Medical College, Kolkata over a period of one year. Results: There was statistically significant improvement in NIHSS (p value-0.000) after intravenous thrombolysis. Conclusions: IV thrombolysis is feasible for AIS in governmental hospital in India. Keywords: Atherothrombosis, Cardioembolic, Dyslipidaemia, Ischemic stroke, Thrombolysis 1 Department of Neurology, NRS Medical College, Kolkata, West Bengal, India 2 Department of Neurosurgery, Hyogo College of Medicine, Japan 3 Department of Neurology, Calcutta National Medical College, Kolkata, West Bengal, India Received: 29 September 2019 Accepted: 01 November 2019 *Correspondence: Dr. Manoj Kr. Mahata, E-mail: manojmahata85@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-3933.ijam20195240