International Journal of Organic Chemistry, 2017, 7, 346-368 http://www.scirp.org/journal/ijoc ISSN Online: 2161-4695 ISSN Print: 2161-4687 DOI: 10.4236/ijoc.2017.74029 Dec. 15, 2017 346 International Journal of Organic Chemistry Fatty Acids in Heterocyclic Synthesis. Part XVII: Synthesis of Non Ionic Surfactants Containing Piperidine, Piperazine, Imidazole Based on Thiadiazole and Microbiological Activities Evaluation Abdelmotaal Abdelmajeid, Mahasen Saad Amine, Reda Ali Hassan Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt Abstract A series of novel scaffolds Thiadiazolyl Piperidine, Thiadiazolyl Piperazine, thiadiazolidine, Thiadiazolyl thiazole and Thiadiazolyl-imidazole-Thione were synthesized from cheap, available and biologically active stearic acid. 2-amino-5-heptadecyl 1,3,4-thiadiazole reacts with chloroacetyl chloride and produced 2-choloro-N-(5-heptadecyl-1,3,4-Thiadiazole-2-yl) acetamide. Which allowed to react with Piperidine, Piperazine, urea and/or Thiourea and Potas- sium thiocyanate, and the latest scaffolds have been synthesized, respectively, and the structures of these compounds were established by elemental analysis, MS, IR and 1 H-NMR spectral data. The antimicrobial activities of the synthe- sized compounds were evaluated in-vitro against strains of gram +ve, gram −ve bacteria and fungi. Nonionic surfactant were obtained by addition of different moles of propylene oxide (3,5,7 mole) to the synthesized compounds bearing an active hydrogen. Physico-chemical and surface properties as well as biodegrada- bility of the synthesized non-ionic surfactants were evaluated. Keywords 2-Aminothiadiazole, Imidazole, Thiazole, Stearic Acid, Thiazolidine, Propylene Oxide, Nonionic Surfactant, Antimicrobial Activity 1. Introduction 1,3,4-Thiadiazole and its derivatives continue to be of great interest owing to their great pharmaceutical and industrial importance. The specific pharmaco- How to cite this paper: Abdelmajeid, A., Amine, M.S. and Hassan, R.A. (2017) Fatty Acids in Heterocyclic Synthesis. Part XVII: Synthesis of Non Ionic Surfactants Con- taining Piperidine, Piperazine, Imidazole Based on Thiadiazole and Evaluation of the Microbiological Activities. Internation- al Journal of Organic Chemistry, 7, 346-368. https://doi.org/10.4236/ijoc.2017.74029 Received: June 3, 2017 Accepted: December 12, 2017 Published: December 15, 2017 Copyright © 2017 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access