Eur Urol Suppl 2008;7(3):109 153 WITHDRAWN 154 EFFICACY AND SATISFACTION OF TWO MINIMALLY INVASIVE TECHNIQUES FOR THE TREATMENT OF DISTAL URETERAL LITHIASIS IN THE MALE. A RANDOMISED, PROSPECTIVE, COMPARATIVE STUDY Bonillo Garcia M.A., Budia Alba A., Broseta Rico E., Pontones Moreno J.L., Oliver Amoros F., Boronat Tormo F., Jimenez-Cruz J.F. La Fe University Hospital, Dept. of Urology, Valencia, Spain Introduction & Objectives: ureterorenoscopy and intracorporeal lithotripsy with holmium laser (URS) vs. Extracorporeal shock wave lithotripsy (ESWL) in the treatment of distal ureteral calculi of the male. Material & Methods: A total of 80 males diagnosed of distal ureteral lithiasis were included in the study. Fourteen out of the initial 80 patients (17.5%) did not complete the follow-up and were excluded from this series. Accordingly a total of 66 patients were prospectively randomized to either ESWL under mild sedation with pethidine each, or URS and intracorporeal holmium YAG laser lithotripsy and/or stone retrieval with endoscopic forceps under general or spinal anesthesia (28 patients, 42.4%). The Results: the lithiasis were <1 cm vs. 57.1% in the URS group). Stone-free rate for the URS group was 96.4% (27) vs. 50% (16) in ESWL group. For the <1 cm lithiasis sub-group URS both groups. Multivariate analysis by logistic regression model using all factors showed distal ureteral stone clearance in the male was 26 times higher in the URS group than in in both groups (96.4% for URS and 89.7% for ESWL groups respectively). Conclusions: This study demonstrated that for distal ureteral stones in the male, URS lithiasis bigger than 1 cm and with a high satisfaction rate. 155 THE PREVALENCE OF RANDALL’S PLAQUES IN STONE FORMERS VERSUS NON-STONE FORMERS Chopra S., Mayer E.K., Smith R.D., Patel A. St. Mary’s Hospital, Dept. of Urology, London, United Kingdom Introduction & Objectives: There has historically been much debate over the presence of Randall’s plaques and their role in the pathogenesis of stone disease. This study’s objective was to accurately ‘map’ the number and ureterorenoscopy irrespective of indication, to test the hypothesis that the formers (SF) and non-stone formers (NSF). Material & Methods: All patients undergoing either diagnostic or therapeutic year period were included in the study. A systematic approach was used to examine all papillae and images were recorded by digital video. The presence or absence of papillary plaques and/or stones was documented. The calyces facilitate locational description because of the variability in the total number of calyces and papillae in each kidney. Results: current or previous history of stone disease (SF) and 17 had no history of stone 26.8% were in the UC, 28.4% in the MC and 44.7% in the LC. In NSF, 117/169 Conclusions: the prevalence and distribution of Randall’s plaques in the kidneys of stone forming and non-stone forming patients. This observation would support the theory that there are other forces driving stone formation (whether the stone originates on a plaque or not) rather than the mere presence of a Randall’s plaque being a risk factor for stone formation in its own right. P9 PENIS: CANCER AND RECONSTRUCTIVE SURGERY Wednesday, 26 March, 14.30-16.00, White Hall 1 156 GENETIC IMBALANCES IN PENILE SQUAMOUS CELL CARCINOMA DETECTED BY COMPARATIVE GENOMIC HYBRIDIZATION Becker U. 1 , Romics I. 2 , Moravek P. , Szendroi A. 2 , Riesz P. 2 , Schubert J. 1 , Junker K. 1 1 Friedrich-Schiller-University, Dept. of Urology, Jena, Germany, 2 Semmelweis University, Dept. of Urology, Budapest, Hungary, Charles University, Dept. of Urology, Hradec Kralove, Czech Republic Introduction & Objectives: Up to now many studies about diagnostics, therapeutic regimes and clinical prognostic factors in patients with penile cancer exist. Only little information is known about genetic alterations leading to the development and comparative genomic hybridization (CGH) on squamous cell carcinoma of the penis with and without lymphatic metastases. Material & Methods: cases of penile carcinoma patients who underwent surgery between 1990 to 2004. was analysed by CGH according to standard protocols. Results: cases. All cases without genetic aberration had also no lymph node metastases. 6.5 metastases respectively. CGH-analyses showed aberrations of nearly all chromosomes at varying frequencies. The most common copy number gains were detected at the median number of alterations per tumour was lower in patients with metastases (5.6 vs. a survival time of less than - or equal to 24 month a lower number of DNA-losses was detected. Conclusions: unbalanced chromosomal aberrations. Especially less chromosomal aberrations seemed to be associated with shorter survival time. Cases with lymph node metastases showed a lower number of deletions as well as a lower number of DNA copy gains in cases without metastases.