2 AJR:212, January 2019
tions seldom happen, most radiologists have
had little to no experience in managing them.
In one study specifcally assessing knowledge
of using epinephrine within a radiology depart -
ment, a drug integral to the treatment of mod-
erate and severe adverse reactions, only 50% of
participants identifed the correct dose of intra-
muscular epinephrine and only 29% knew the
dose for IV epinephrine [5].
At the University of Chicago Medical Cen-
ter, two live didactic lectures covering diagno-
sis, determination of severity, and management
of contrast media reactions have traditionally
been provided to radiology residents by a ra-
diologist and radiology nurse. However, stud-
ies suggest didactic lectures alone may not pro-
vide adequate training [6]. Multiple studies have
found that high- fdelity simulations are useful
to provide the necessary training and a means
of assessing residents’ skills and comfort levels
[7]. In addition, knowledge retention has been
High-Fidelity Simulation Training
for the Diagnosis and Management
of Adverse Contrast Media
Reactions
Saad Ali
1
Anup Alexander
1,2
Marcie Lambrix
3
Rishi Ramakrishna
1,2
Carina W. Yang
1
Ali S, Alexander A, Lambrix M, Ramakrishna R,
Yang CW
1
Department of Radiology, University of Chicago Medical
Center, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
Address correspondence to S. Ali (saadali@uchicago.edu).
2
Department of Radiology, NorthShore University Health-
System Evanston Hospital, Evanston, IL.
3
Simulation Center, University of Chicago, Chicago, IL.
Special Articles • Original Research
Supplemental Data
Available online at www.ajronline.org.
AJR 2019; 212:2–8
0361–803X/19/2121–2
© American Roentgen Ray Society
T
he frequency of adverse contrast
media reactions to nonionic io-
dinated contrast has been report-
ed to range from 0.2% to 0.4%,
with some studies reporting up to 0.7% [1, 2].
A large study in China reviewing 109,255
cases stratifed incidence based on severity,
reporting 0.26% for mild reactions, 0.07% for
moderate reactions, and 0.01% for severe reac-
tions [3]. The frequency of adverse reactions
to gadolinium, in comparison, has been re-
ported by the U.S. Food and Drug Adminis-
tration to range between 0.04% and 2.2% [4].
Although fairly uncommon, contrast media
reactions are potentially life-threatening events
that require prompt recognition and manage-
ment by radiologists. Especially in the setting
of a moderate to severe reaction, radiologists
must be able to recognize and manage con-
trast media reactions, at least until the arrival
of a code team. Because contrast media reac-
Keywords: contrast medium reaction, simulation
doi.org/10.2214/AJR.18.19864
Received March 19, 2018; accepted after revision
July 16, 2018.
Based on presentations at the 2015 annual meeting of the
American College of Radiology, Washington, DC; the 2015
annual meeting of the Chicago Simulation Consortium,
Chicago, IL; and the 2016 annual meeting of the Society
for Simulation in Healthcare, San Diego, CA.
OBJECTIVE. Adverse reactions to contrast media are potentially life-threatening events
that require prompt recognition and management by radiologists who may have little experi-
ence with them. The objectives of this project were to develop and assess a simulation-based
program that would equip radiology trainees with appropriate knowledge and skills to recog-
nize and manage adverse contrast media reactions.
MATERIALS AND METHODS. Fifteen adverse contrast media reaction scenarios
were developed to run on high-fdelity adult and pediatric mannequins in a simulation cen-
ter. Ninety-six radiology trainees (postgraduate year 2–6) participated in the program, which
consisted of two didactic lectures and a simulation session. For each simulation session, seven
scenarios were chosen. Objective quizzes assessing knowledge and subjective questionnaires
assessing comfort were completed both before and after the simulation. A survey assessing
the overall program was also completed.
RESULTS. All 96 radiology trainees viewed the didactic lectures, attended a simulation
session, and completed the pre- and postsimulation quizzes and questionnaires. Mean scores
increased from 69% to 82% ( p < 0.001) and from 3.1 to 4.5 out of 5 ( p < 0.001) on the ob-
jective and subjective tests, respectively. Statistically signifcant improvement was also seen
when participants were separated according to level of training. On the fnal program evalua-
tion survey, scores ranged from 4.5 to 4.7 out of 5.
CONCLUSION. We describe the development of a high-fdelity simulation program with
a larger variety of scenarios than in prior studies that can provide radiologists the knowledge
and skills needed to recognize and manage adverse contrast media reactions. We saw a statis-
tically signifcant improvement in knowledge and comfort levels across all levels of training.
Ali et al.
Contrast Media Reaction Simulation Training
Special Articles
Original Research
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