ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org An International Open Free Access, Peer Reviewed Research Journal ISSN: 0970-020 X CODEN: OJCHEG 2018, Vol. 34, No.(5): Pg. 2342-2349 This is an Open Access article licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/), which permits unrestricted Non Commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Study of Potential Phenolic Compounds from Stems of Dendrophthoe falcata (Loranthaceae) Plant as Antioxidant and Antimicrobial Agents SRI ATUN 1 *, SRI HANDAYANI 1 , ANNA RAKHMAWATI 2 , NUR AINI PURNAMANINGSIH 2 , BIAN IHDA AN NAILA 1 and ASTUTI LESTARI 1 1 Department Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta, Indonesia. 2 Department of Biology Education, Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta, Indonesia. *Corresponding author E-mail: sriatun@uny.ac.id http://dx.doi.org/10.13005/ojc/340515 (Received: April 04, 2018; Accepted: October 15, 2018) ABSTRACT Dendrophthoe falcata is a hemiparasitic plant that has been used in traditional medicine. The study was conducted to identify the total phenolic and flavonoid compounds, to test antioxidant, and antimicrobial activity of ethanol extract stems of D. falcata parasite on Melia azedarach host tree. The dry powder stems of D. falcata was extracted with ethanol. The ethanol extract was subsequently partitioned successively using n-hexane, chloroform, and ethyl acetate. Each fraction was analyzed by a quantitative phenolic and flavonoid content with spectrophotometer method, and tested as antioxidant and antimicrobial activites. Antioxidant activity was performed by 2,2-diphenyl- 1-picrilhidrazil (DPPH) method, while antimicrobial assay used pathogenic bacteria by disk-diffusion method. The results concluded that the stem of D. falcata plant showed a high content of phenolic and flavonoid compounds, very high antioxidant and moderate antimicrobial activities. It was also found that stems of D. falcata contain potential phenolic compounds that can be used as natural antioxidants and the treatment of various infections caused by microbes. Keyword: Dendrophthoe falcata, Antioxidant. Antimicrobial. Phenolic compound, Flavonoids. INTRODUCTION Loranthacea is a parasitic plant widely used in traditional Chinese medicine systems. One of this species is L. parasiticus which is known as Sang Ji Sheng (in Chinese), parasites (in Malay) and baso-Kisei (in Japanese). The plants are commonly found as parasitic plants that attach to other plant stems. Parasites can be found in tropical and sub- tropical regions, but with different species diversity. 1-4 L. parasiticus known as traditional medicine is widely used as a diuretic, high blood pressure,