S1 Supporting Information Synthesis, SAR and biological studies of sugar amino acid based almiramide analogues: N-methylation leads the way Dipendu Das, a Hina P. A. Khan, b Rahul Shivahare, c Suman Gupta, c Jayanta Sarkar, d Mohd. Imran Siddiqui, e Ravi Sankar Ampapathi,* f Tushar Kanti Chakraborty* b CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Department of Organic Chemistry, Indian Institute of Science, CV Raman Road, Bengaluru 560012, India tushar@orgchem.iisc.ernet.in Table of Contents: 1. General Experimental Details and Instrumentation: S2 2. Spectra ( 1 H and 13 C NMR) of Compounds: S3-S34 3. SAR studies S35-S40 4. NMR studies S41-S52 5. RPHPLC Chromatograms S53-S64 Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is © The Royal Society of Chemistry 2017