1 TITLE PAGE Confirming Diagnosis of Hazardous and Harmful Alcohol Use Diagnostic accuracy of a computer assisted diagnostic system compared to conventional markers of alcoholism. Aleksander Korzec, MD, Carla de Bruijn, MD, Michiel van Lambalgen, PhD Key words: sensitivity, specificity, harmful alcohol use, confirmation, computer assisted diagnostic system Word count paper : 3194 Word count abstract : 293 Authors Affiliations: Sint Lucas Andreas Hospital, Amsterdam, the Netherlands, (Korzec, psychiatrist and de Bruijn, psychiatric resident); University of Amsterdam. Amsterdam, The Netherlands (van Lambalgen, professor of logic and artificial intelligence). Corresponding author: A.Korzec, MD. Sint Lucas Andreas Ziekenhuis, box 9423, 1006 AE Amsterdam, the Netherlands tel. 0031 20 5108562; fax 0031 20 6126431; e-mail: a.korzec@slaz.nl Acknowledgements All laboratory tests, except carbohydrate-deficient transferrin (CDT) were performed in the Department of Clinical Chemistry, St Lucas Andreas Hospital, Amsterdam, the Netherlands (Dr W de Kieviet). CDT was performed at bioscientia, Ingelheim, Germany.