Afif M.Yusof et al JMSCR Volume 03 Issue 11 November Page 8239 JMSCR Vol||3||Issue||11||Page 8239-8244||November 2015 Olfactory Neuroblastoma with Metastasis to Parotid Gland: A case report Authors Afif M.Yusof, Nur Asyilla Che Jalil, Anani Aila Mat Zin, Department of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia Abstract Olfactory neuroblastoma also known as esthesioneuroblastoma is uncommon malignant neoplasm usually occur at roof of nasal cavity. It usually metastasize to lymph node and rarely metastatise to parotid gland. There has been only one case reported regarding metastasis of ONB to parotid gland in 2005 [7] . We report a case of elderly women with diagnosis of olfactory neuroblastoma presented with parotid swelling 2 months after the operation which is progressively increases in size. Histopathology and immunohistochemistry confirm the diagnosis of olfactory neuroblastoma metastasize to parotid gland. The patient underwent total parotidectomy, tumour debulking, left cervical lymph node removal with preservation of facial nerve branches and left selective neck dissection was performed. Patient is planned for further chemotherapy and palliative care Introduction Olfactory neuroblastoma is umcommon malignancy of olfactory sensory epithelium of nasal cavity, neural in origin arising from olfactory neuroblastoma first described by Berger et al in 1942 [5, 6, 15] . Now the tumour is established as neuroectodermal tumour arises from roof of latera lwall of the nose. The olfactory neuroblastoma exhibiting wide range of hitopathological findings and give difficulty in the diagnosis. [5, 6, 15] . Clinical finding, radilogical and immunohistochemistry correlation is very important to reach to the diagnsois. Patient usually presented with nasal obstruction, epistaxis, rhinorrhea, headache and visual disturbance.The tumour is known to be locally invasive tend to spread to surrounding strucures and frequent locall recurrent is reported. Isolated metastasize to parotid gland without continuous extension is very rare. [1] Case Report A 58 years postmenopausal woman, with underlying hypertension and type 2 Diabetes Mellitus known case of olfactory neuroblastoma was referred from another centre for further treatment. At first presentation, she complained of bilateral epistaxis and anosmia associated with memory impairment, lost of vision, headache, intermittent fever, lethargy, loss of appetite and loss of weight for 6 months duration. Initial examination revealed a mass arising from the left middle turbinate measuring 4x4 cm. Fossa of Rosenmuller was normal and no lymph node was www.jmscr.igmpublication.org Impact Factor 3.79 Index Copernicus Value: 5.88 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v3i11.21