© 2019 Hijjaw et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Open Access Rheumatology: Research and Reviews 2019:11 11–18 Open Access Rheumatology: Research and Reviews Dovepress submit your manuscript | www.dovepress.com Dovepress 11 ORiginAl ReseARch open access to scientific and medical research Open Access Full Text Article http://dx.doi.org/10.2147/OARRR.S188937 correlation between Xerostomia index, clinical Oral Dryness scale, and essPRi with different hyposalivation tests Ola hijjaw 1 Mohammad Alawneh 1 Khaled Ojjoh 1 hazem Abuasbeh 1 Ahmad Alkilany 1 nabeel Qasem 1 Mohammad Al-essa 1 saif Aldeen AlRyalat 2 1 Department of internal Medicine, The University of Jordan, Amman 11942, Jordan; 2 Department of Ophthalmology, The University of Jordan, Amman 11942, Jordan Background and objective: Xerostomia is a subjective measure of dry mouth, while hyposali- vation is an objective measure of reduced saliva flow rate. In this study, we aim to assess the association between commonly used xerostomia scoring systems, with different hyposalivation measures among Sjogren Syndrome (SS) patients. Methods: In a cohort of SS patients, we assessed xerostomia using Xerostomia index, clinical oral dryness scale (CODS), and the European League Against Rheumatism SS Patient-Reported Index (ESSPRI), and we assessed hyposalivation using unstimulated whole saliva flow (UWS), stimulated whole saliva flow (SWS), and stimulated parotid flow (SPF). We analyzed the asso- ciation between xerostomia and hyposalivation using association tests in SPSS. Results: We included a total of 49 patients in this study, of which 34 (68%) had primary SS, and 15 (32%) had secondary. CODS was significantly correlated with SWS (P=0.048), with a negative correlation coefficient of 0.216, and with SPF (P=0.009), with a negative correlation coefficient of 0.291. The dryness domain of ESSPRI was significantly correlated with UWS (P=0.031) with a negative correlation coefficient of 0.233. Conclusion: CODS is the scoring system with the highest correlation with hyposalivation, particularly SWS and SPF, followed by ESSPRI dry domain, which is correlated with UWS. Xerostomia index is not correlated with hyposalivation. Keywords: Sjogren syndrome, xerostomia, hyposalivation, XI, CODS, ESSPRI Introduction Sjogren’s syndrome (SS) is a chronic autoimmune disease affecting mainly the exocrine glands, especially the lacrimal and salivary glands. It is the second most common autoimmune rheumatic disease. 1 Its prevalence ranges between 0.1% and 4.8% with a female to male ratio of 9:1, mostly in the age of 40–60 years. 2 Generally, SS is clas- sified into primary SS, which occurs alone without any other associated disease, and secondary SS, which is associated with other diseases such as rheumatoid arthritis and systemic lupus erythematosus. 3 SS has a wide variety of presentations and can affect almost any organ, but it typically presents with dryness of eyes and mouth. 4 Xerostomia and hyposalivation are two concepts used in the diagnostic criteria of SS, which are distinguishable from each other. Xerostomia is a subjective measure, when the patient reports a daily feeling of dry mouth, while hyposalivation is an objective quantifi- able measure of reduced saliva flow rate. 5 Multiple scoring system has been developed to assess xerostomia and several tests for hyposalivation. Three scoring systems we will discuss in our study include Xerostomia index (XI), clinical oral dryness scale (CODS), and the European League Against Rheumatism SS Patient-Reported Index correspondence: saif Aldeen AlRyalat Department of Ophthalmology, The University of Jordan, Queen Rania str., Amman 11942, Jordan Tel +962 798 914 594 email saifryalat@yahoo.com Open Access Rheumatology: Research and Reviews downloaded from https://www.dovepress.com/ by 54.162.69.248 on 25-May-2020 For personal use only. 1 / 1