Niharika Kotian, Ganesh Jeevanandan, S Rajeshkumar. Assessment Of Anti-Infammatory Effect Of Three Different Silver Diamine Fluoride- An In Vitro Study. Int J Dentistry Oral Sci. 2021;8(7):3300-3302. 3300 OPEN ACCESS https://scidoc.org/IJDOS.php Niharika Kotian 1 , Ganesh Jeevanandan 2* , S Rajeshkumar 3 . 1 Post-Graduate Student, Department Of Pedodontics, Saveetha Dental College And Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. 2 Reader, Department Of Pedodontics, Saveetha Dental College And Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. 3 Associate Professor, Department of Pharmacology, Saveetha Dental College And Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. International Journal of Dentistry and Oral Science (IJDOS) ISSN: 2377-8075 *Corresponding Author: Ganesh Jeevanandan Reader, Department Of Pedodontics, Saveetha Dental College And Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. Tel: +91 9884729660 E-mail: orthoravi2@gmail.com Received: May 05, 2021 Accepted: July 08, 2021 Published: July 18, 2021 Citation: Niharika Kotian, Ganesh Jeevanandan, S Rajeshkumar. Assessment Of Anti-Infammatory Effect Of Three Different Silver Diamine Fluoride- An In Vitro Study. Int J Dentistry Oral Sci. 2021;8(7):3300-3302. doi: http://dx.doi.org/10.19070/2377-8075-21000672 Copyright: Ganesh Jeevanandan © 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Introduction Early childhood caries caries is a preventable disease that has be- come a serious concern in developed as well as developing coun- tries. It not only affects the health but also has an impact on the quality of life[1]. The usage of fuoride varnishes and dentifrices has helped in decreasing the rate of caries in children[2]. Carious lesions can be managed by removal of the caries and re- storing the cavity using a suitable material[3]. The cavity can be restored by either conventional methods or by minimal invasive dentistry, where the latter helps in preserving sound tooth struc- ture[4]. Silver diamine fuoride is gaining its interest in the feld of pedi- atric dentistry due to its ability to arrest a carious lesion. This property is particularly very helpful in young children where they refuse to undergo any dental procedure due to fear or in individu- als with special health care needs[5]. Silver diamine fuoride is composed of ammonia, silver and fuo- ride. There is a variation in the amount of fuoride in different brands[6]. Silver diamine fuoride has both anti-bacterial as well as remineralizing properties[7,8]. The fuoride component in Silver diamine fuoride helps in strengthening the tooth structure and reversing the demineralizing effect caused by the microorgan- isms[9]. Silver diamine fuoride is usually indicated in children with high risk for caries on any surface of primary teeth or even in the per- manent molars. It is contraindicated in carious lesions involving pulp and in individuals having silver allergy. Silver diamine fuo- Abstract Aim :To compare and evaluate the anti – infammatory effect of Kedo- SDF, Kids-e SDF and Fagamin SDF. Materials And Methods:The three different Silver diamine fuoride solutions(Fagamin,Kids-e and Kedo) were prepared in different test tubes. 1 ml of the silver diamine fuoride solution was added to 10-20 ml disilled water at various fxations. This was added to 0.45 mL bovine serum albumin. pH of the mixture was acclimated to 6.3 with 1N hydrochloric acid. Absorbance was measured spectrophotometrically at 660 nm. Diclofenac sodium was used as the standard group. Results : At 40μL concentration KedoSDF had higher anti infammatory as compared to the other groups including the standard group. At 50μL concentration Kedo SDF and Kids-e SDF had equal anti-infammatory action and it was higher than Fagamin SDF and the standard group. Conclusion: It can be concluded that Kedo silver diamine fuoride solution exhibited higher anti-infammatory activity as compared to Fagamin solution and Kids-e solution and hence it can be used. The authors also recommend to conduct in-vitro studies in the future based on the anti-infammatory action of different specimens of silver diamine fuoride. Assessment Of Anti-Infammatory Effect Of Three Different Silver Diamine Fluoride- An In Vitro Study Research Article