Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor Cristina Puy 1,2 , Erik I. Tucker 1,3 , Anton Matafonov 4 , Qiufang Cheng 4 , Keith D. Zientek 5 , Dave Gailani 4 , András Gruber 1,2,3 , Owen J.T. McCarty 1,2,6 Departments of 1 Biomedical Engineering, 2 Division of Hematology and Medical Oncology, and 6 Cell & Developmental Biology, School of Medicine, Oregon Health & Science University, Portland, OR; 3 Aronora, Inc, Portland, OR; 4 Department of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, TN . 5 Research Department, Shriners Hospitals for Children, Portland, OR. Running title: FXIa inhibits the function of TFPI Address correspondence to: Cristina Puy, Department of Biomedical Engineering, Oregon Health & Science University, CHH-13B, 3303 SW Bond Ave, Portland, OR 97239; Tel: 503-418-9307; Fax: 503- 418-9311; email: puygarci@ohsu.edu Blood First Edition Paper, prepublished online January 13, 2015; DOI 10.1182/blood-2014-10-604587 Copyright © 2015 American Society of Hematology For personal use only. on May 2, 2017. by guest www.bloodjournal.org From