Doosti-Irani A et al. Melatonin Supplementation and Glycemic Control … Horm Metab Res 2018; 50: 783–790 Review Doosti-Irani Amin et al. The Efects of Melatonin … Horm Metab Res 2018; 00: 00–00 The Efects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Authors Amin Doosti-Irani 1, 2 , Vahidreza Ostadmohammadi 3 , Naghmeh Mirhosseini 4 , Mohammad Ali Mansournia 5 , Russel J. Reiter 6 , Maryam Kashanian 7 , Maryam Rahimi 7 , Maryamalsadat Razavi 8 , Zatollah Asemi 3 Afliations 1 Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran 2 Modeling of Noncommunicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran 3 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran 4 School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada 5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 6 Department of Cellular and Structural Biology, UT Health San Antonio, TX, USA 7 Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 8 Department of Gynecology and Obstetrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Key words melatonin, glycemic control, insulin resistance, meta-analysis received 07.09.2018 accepted 25.09.2018 Bibliography DOI https://doi.org/10.1055/a-0752-8462 Horm Metab Res 2018; 50: 783–790 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence Zatollah Asemi, PhD Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences Kashan Iran Tel.: + 98/31/55463 378, Fax: + 98/31/55463 377 asemi_r@yahoo.com AbstRAct This systematic review and meta-analysis of randomized con- trolled trials (RCTs) was conducted to clarify the efect of mel- atonin supplementation on glycemic control. Databases includ- ing PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched until July 30th, 2018. Two reviewers independently assessed study eli- gibility, extracted data, and evaluated the risk of bias for includ- ed trials. Heterogeneity among included studies was assessed using Cochran’s Q test and I-square (I 2 ) statistic. Data were pooled using random-efect models and mean diference (MD) was considered as the overall efect size. Twelve trials out of 292 selected reports were identifed eligible to be included in current meta-analysis. The pooled fndings indicated that me- latonin supplementation signifcantly reduced fasting glucose (MD = –6.34; 95 % CI, –12.28, –0.40; p = 0.04; I 2 : 65.0) and in- creased the quantitative insulin sensitivity check index (QUICKI) (MD = 0.01; 95 % CI, 0.00, 0.02; p = 0.01; I 2 : 0.0). However, me- latonin administration did not signifcantly infuence insulin levels (MD = –1.03; 95 % CI, –3.82, 1.77; p = 0.47; I 2 : 0.53), homeostasis model assessment of insulin resistance (HOMA-IR) (MD = –0.34; 95 % CI, –1.25, 0.58; p = 0.37; I 2 : 0.37) or HbA1c levels (MD = –0.22; 95 % CI, –0.47, 0.03; p = 0.08; I 2 : 0.0). In summary, the current meta-analysis showed a promising efect of melatonin supplementation on glycemic control through reducing fasting glucose and increasing QUICKI, yet additional prospective studies are recommended, using higher supple- mentation doses and longer intervention period, to confrm the impact of melatonin on insulin levels, HOMA-IR and HbA1c. 783 This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.