_____________________________________________________________________________________________________ *Corresponding author: E-mail: drhajikhan786@gmail.com; Journal of Pharmaceutical Research International 32(36): 36-41, 2020; Article no.JPRI.62835 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Effects of Berberine on Bloog Glucose, Glycated Hemoglobin A 1 , Serum Insulin, C–Peptide, Insulin Resistance and β– Cell Physiology Haji Khan Khoharo 1* , Din Muhammad Shaikh 1 , Ghulam Shah Nizamani 2 , Tariq Zaffar Shaikh 3 , Ikramuddin Ujjan 4 and Arslan Ahmed Uqaili 1 1 Department of Physiology, Faculty of Medicine & Allied Medical Sciences, Isra University, Hyderabad, Sindh, Pakistan. 2 Department of Pathology/Hematology, Faculty of Medicine & Allied Medical Sciences, Isra University, Hyderabad, Sindh, Pakistan. 3 Department of Medicine, Liaquat University of Medical and Health Sciences, Hospital, Jamshoro/Hyderabad, Sindh, Pakistan. 4 Department of Pathology, Liaquat University of Medical and Health Sciences, Hospital Jamshoro/Hyderabad, Sindh, Pakistan. Authors’ contributions This work was carried out in collaboration among all authors. Authors HKK, DMS and GSN designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors HKK, TZS and IU managed the biochemical analysis and analyses of the study. Author HKK and AAU managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2020/v32i3630988 Editor(s): (1) Dr. Syed A. A. Rizvi, Nova Southeastern University, USA. Reviewers: (1) Nazula Rahma Shafriani, Universitas ‘Aisyiyah Yogyakarta, Indonesia. (2) Buchi N. Nalluri, K. V. S. R. Siddhartha College of Pharmaceutical Sciences, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/62835 Received 10 September 2020 Accepted 14 November 2020 Published 21 December 2020 ABSTRACT Objective: Determine effects of berberine (BBR) on bloog glucose, glycated hemoglobin A1, serum insulin, C – peptide, insulin resistance and β– cell physiology. Study Design: Experimental study Place and Duration: Department of Physiology Isra University and Animal house of Sindh Agriculture University, Tando Jam from August 2019 to February 2020. Original Research Article