Accepted Manuscript Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer’s disease Rangappa S. Keri, Catarina Quintanova, Sérgio M. Marques, A. Raquel Esteves, Sandra M. Cardoso, M. Amélia Santos PII: S0968-0896(13)00464-1 DOI: http://dx.doi.org/10.1016/j.bmc.2013.05.028 Reference: BMC 10854 To appear in: Bioorganic & Medicinal Chemistry Received Date: 15 April 2013 Revised Date: 9 May 2013 Accepted Date: 17 May 2013 Please cite this article as: Keri, R.S., Quintanova, C., Marques, S.M., Raquel Esteves, A., Cardoso, S.M., Amélia Santos, M., Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi- targeted compounds against Alzheimer’s disease, Bioorganic & Medicinal Chemistry (2013), doi: http://dx.doi.org/ 10.1016/j.bmc.2013.05.028 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.