_____________________________________________________________________________________________________ *Corresponding author: E-mail: brighthope@rocketmail.com; Journal of Applied Life Sciences International 16(2): 1-7, 2018; Article no.JALSI.38808 ISSN: 2394-1103 Anticonvulsant Potential of Ethanolic Extract of Aspilia africana Leaf in Mice Ozakieoniso James Kemelayefa 1 and Hope Delesi Kagbo 2* 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. 2 Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria. Authors’ contributions This work was collaboration between the two authors. Authors OJK and HDK designed the study and performed the statistical analysis. Author OJK managed the literature searches and wrote the first draft of the manuscript. While author HDK proof-read the manuscript to make corrections. Both authors read and approved the final manuscript. Article Information DOI: 10.9734/JALSI/2018/38808 Editor(s): (1) Purnachandra Nagaraju Ganji, Department of Hematology and Medical Oncology, Emory University School of Medicine, USA. Reviewers: (1) Suprakash Chauhdury, Dr. D. Y. Patil Vidyapeeth, India. (2) Syed Mohd Abbas Zaidi, HSZH Govt. Unani Medical College, India. Complete Peer review History: http://www.sciencedomain.org/review-history/23137 Received 14 th October 2017 Accepted 4 th January 2018 Published 12 th February 2018 ABSTRACT Aim: This study was carried out to determine the anticonvulsant potential of A. africana leaf extract in its polar (ethanol) constituents. Study Design: The study was adapted from three methods of seizure stimulation of the in vivo animal model using the maximal electroshock (MES), pentylenetetrazole (PTZ), strychnine (STC) methods and in addition, motor coordination. Place and Duration of Study: The study was carried out in the laboratory of the Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria between August to October, 2017. Methodology: The powdered leaf of A. africana (2000 g) was extracted cold in 10 litres of ethanol (50%). The extraction was made using rotary evaporator at a maximum temperature 45°C. The total dried extract obtained from the 2000 g powdered leaves of A. africana was 216.4 g given 10.8% w/w yield. The dose was established based on preliminary data that proof ratio 1/33 of the Original Research Article