ISSN 1477-0520 www.rsc.org/obc Volume 7 | Number 5 | 7 March 2009 | Pages 817–1028 FULL PAPER Hans-Joachim Knölker et al. Synthesis and biological activity of the (25R)-cholesten-26-oic acids—ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans PERSPECTIVE Teather J. Sundstrom et al. Inhibitors of phosphoinositide-3- kinase: a structure-based approach to understanding potency and selectivity