_____________________________________________________________________________________________________ *Corresponding author: E-mail: zontuisa@yahoo.com; Journal of Advances in Medical and Pharmaceutical Sciences 15(3): 1-9, 2017; Article no.JAMPS.37768 ISSN: 2394-1111 Effects of Citrus Limon Juice on Serum Bilirubin, High Density Lipoprotein and Low Density Lipoprotein in Adult Male Wistar Rats under Variable Models of Stress Anachuna Kenneth Kelechi 1* , Daubry Tarela Melish Elias 1 , Ewhre Oberhiri Lawrence 2 and Oyem John Chukwuma 3 1 Department of Human Physiology, Delta State University, Abraka, Delta State, Nigeria. 2 Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria. 3 Department of Human Anatomy, Delta State University, Abraka, Delta State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author AKK designed the study and wrote the protocol. Authors DTME and EOL managed the animals and the field study. Authors AKK, EOL and OJC conducted laboratory analysis and collected all data. Authors DTME and EOL performed the statistical analysis and author AKK wrote the first draft of the manuscript. Authors AKK and DTME did the literature search and completed the manuscript. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMPS/2017/37768 Editor(s): (1) Julius Olugbenga Soyinka, Department of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria. Reviewers: (1) Dinithi Peiris, University of Sri Jayewardenepura, Sri Lanka. (2) Bhaskar Sharma, Suresh Gyan Vihar University, India. Complete Peer review History: http://www.sciencedomain.org/review-history/22058 Received 27 th October 2017 Accepted 19 th November 2017 Published 25 th November 2017 ABSTRACT Introduction: There has been sufficient awareness on atherosclerosis but this has not reduced the number of people with it. Atherosclerosis is promoted by low density lipoprotein (LDL) without sufficient removal of fats and cholesterol by high density lipoprotein (HDL). Stress is linked with hyperlipidemia, lowering HDL and increasing LDL levels. Citrus Limon is known for its rich minerals and flavonoid content which have been employed widely. This study is aimed at assessing the hypolipidemic effects of citrus Limon on Bilirubin, HDL and LDL levels. Original Research Article