Cholesterol Uptake Targeted Growth Regulation to Control Disease Transmitting Vector Populations Sarvananda Letchuman 1* , Amal D Premarathna 2 1 Department of Veterinary Biochemistry,University of Peradeniya, Peradeniya, Sri Lanka; 2 School of Natural Sciences and Health, Tallinn University, Tallinn, Estonia ABSTRACT Cholesterol is one of the vital compounds required maintain principal metabolic pathways and structural material in the human and animal body. Insects are lack of the essential enzymes required for the biosynthesis of cholesterol from precursor molecules in nature and which makes them depend on dietary cholesterol. Thus the blocking of cholesterol uptake interfere the metabolic pathways of insects and effects on the survival of the them. Based on this characteristic nature, certain phytochemicals can be applied to inhibit Aegypti Sterol Carrier Protein 2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease transmitting mosquitoes and other insect vectors. Range of candidate compounds and plant sources, that block the cholesterol uptake in insects, can effectively be used to prevent and spread of vector born disease have been discussed. Keywords: Mosquito Vector control Vector borne diseases Cholesterol digestion INTRODUCTION A diverse array of tropical vector borne diseases are transmitted to human through the infected arthropods. Memberes of arthropods of mosquitoes, sand flies, house fly, blackfly, tsetse fly and kissing bugs are mainly responsible for some of the most virulent vector borne diseases in the world [1]. Furthermore, mosquitoes are considered to be the most dangerous group of insects as different species of mosquitoes transmits a range of diseases to man and animal including malaria, dengue, lymphatic filariasis, dirofilariasis and Japanese encephalitis [2]. Moreover, other arthropads transmit diseases such as leishmaniasis (sand flies), enteric diseases (house flies), onchocerciasis (blackfly), trypanosomiasis (tsetse fly) and chagas disease (kissing bugs). Strategic approach to preveting and controlling of vector borne diseases are not only limited to treating patinets but also are mainly depending contol of vector population1. During the pre-dichlorodiphenyltricholoethane (DDT) era, the main vector control stratergies were environmental friendly and biological controlled methods of drainage of swamps and other mosquito breeding sites, clearing of vegetation’s to remove vector resting places and various other traditional means [3,4]. However, discovery of DDT made it looks like the most relieving discovery of the history until the uncontrolled use of this chemical resulted very serious damages to the ecosystems and animals. Consequently, DDT resistant mosquitoes resulted due to mutations1. This example indicates the inability of using of chemicals as a solution to control of vector borne diseases5. Further, insecticides and other chemical resistant arthropod vectors are emerged as a result of long term usage of chemicals to control arthropod density in the environment. Therefore, it is utmost important to invent environmentally friendly and more effective novel insecticides to prevent and minimize any chance of development of a resistance among the arthropods. Insecticides target various metabolic pathways in arthropods that essential for the survival and for the maintenance of their life cycle. In addition, insects that expose to the particular insecticide become incapable of producing the cholesterol which acts as an essential compound in their body structures and as a precursor for molting hormones within their bodies. This makes them dependable on the external sources of cholesterol [5]. Therefore, if there is a process which makes them unable to uptake cholesterol, will be fatal to the target insect. A literature search was carried out in PubMed Central (PMC) looking for research articles that describe pre-clinical studies of inhibition of cholesterol uptake in arthropods. The following E nto m o l o g y , O r n i t h o l o g y & H e rp et ol o g y : C u r r e n t R e s e a rc h ISSN: 2161-0983 Entomology, Ornithology & Herpetology: Current Research Mini-Review Correspondence to: Sarvananda Letchuman, Department of Veterinary Biochemistry, University of Peradeniya, Peradeniya , Sri Lanka, E-mail: sarvacool18@gmail.com Received: September 06, 2021; Accepted: September 20, 2021; Published: September 27, 2021 Citation: Letchuman S, Premarathna AD (2021) Cholesterol Uptake Targeted Growth Regulation to Control Disease Transmitting Vector Populations. Entomol Ornithol Herpetol. 10: 245. Copyright: © 2021 Letchuman S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Entomol,Ornithol&Herpetol, Vol.10 Iss.8 No:1000245 1 ; ; ;