Open Peer Review Any reports and responses or comments on the article can be found at the end of the article. CLINICAL PRACTICE ARTICLE Nonsurgical endodontic management of dens invaginatus: a report of two cases [version 1; peer review: awaiting peer review] Amjad Abu Hasna , Daniela Maria de Toledo Ungaro , Allana Agnes Pereira de Melo , Karen Cristina Kazue Yui , Eduardo Galera da Silva , Frederico Canato Martinho , Ana Paula Martins Gomes 2 Department of Restorative Dentistry, Endodontic Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo, 12245000, Brazil Department of Science and Technology Applied to Dentistry, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo, 12245000, Brazil Department of Restorative Dentistry, Operative Dentistry Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo, 12245000, Brazil Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, Baltimore, USA Abstract Dens invaginatus is a malformation affecting mainly the superior lateral incisors. It is defined as an infolding of the crown hard tissues, including the enamel and dentin, and can extend up to the root apex. Root canal treatment of this abnormality is considered difficult due to the complex anatomy presented by these teeth. This case series presents nonsurgical endodontic treatment in two cases of dens invaginatus (type II and III) in maxillary lateral incisors. This nonsurgical or conventional endodontic treatment results in healing of the periapical lesions associated with both cases, with no need for extra intervention e.g. surgical or invasive management. The manual instrumentation associated with sodium hypochlorite and calcium hydroxide were able to completely heal the lesions. Radiographic exams were carried out to control and asses the healing. Nonsurgical treatment was successful in both cases with adequate repair after a 6-year follow-up with radiographic and tomographic assessments. Keywords Dens invaginatus, Follow-up, Root canal treatment. 1 2 2 3 2 4 2 1 2 3 4 Reviewer Status AWAITING PEER REVIEW 02 Dec 2019, :2039 ( First published: 8 ) https://doi.org/10.12688/f1000research.21188.1 02 Dec 2019, :2039 ( Latest published: 8 ) https://doi.org/10.12688/f1000research.21188.1 v1 Page 1 of 8 F1000Research 2019, 8:2039 Last updated: 02 DEC 2019