Ahmad A. Mohammad, MS, a Sean Z. Wu, BS, b Omer Ibrahim, MD, c James Bena, MS, c Maged Rizk, MD, d Melissa Piliang, MD, c and Wilma F. Bergfeld, MD c St George’s University School of Medicine, True Blue, Grenada, West Indies a ; Case Western Reserve University School of Medicine, Cleveland, Ohio b ; and Departments of Dermatology c and Gastroenterology, d Cleveland Clinic Foundation, Ohio Dr Mohammad and Mr Wu contributed equally to the writing of this letter. Funding sources: None. Conflicts of interest: None declared. Correspondence to: Omer Ibrahim, MD, Depart- ment of Dermatology, 9500 Euclid Ave, A61, Cleveland Clinic Foundation, Cleveland, OH 44195 E-mail: khobel608@hotmail.com REFERENCES 1. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esopha- gitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128(1):3-20.e26. 2. Chadha SN, Wang L, Correa H, Moulton D, Hummell DS. Pediatric eosinophilic esophagitis: the Vanderbilt experience. Ann Allergy Asthma Immunol. 2014;113(4):445-451. 3. Dellon ES, Jensen ET, Martin CF, Shaheen NJ, Kappelman MD. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol. 2014;12(4):589-596.e581. 4. Maradey-Romero C, Prakash R, Lewis S, Perzynski A, Fass R. The 2011-2014 prevalence of eosinophilic esophagitis in the elderly amongst 10 million patients in the United States. Aliment Pharmacol Ther. 2015;41(10):1016-1022. 5. Asher MI, Montefort S, Bjorksten B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006;368(9537):733-743. http://dx.doi.org/10.1016/j.jaad.2016.08.068 Sensitivity and specificity of BP180 NC16A enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis To the Editor: Pemphigoid gestationis (PG) is a rare autoimmune subepidermal bullous dermatosis of pregnancy. PG is associated with circulating autoantibodies targeting the extracellular noncollag- enous domain of the hemidesmosomal protein BP180. Diagnosis of PG is based on direct immuno- fluorescence (DIF) showing linear C3 and/or IgG deposits on the dermoepidermal junction (DEJ). DIF Table II. Comparing patients with eosinophilic esophagitis with or without atopy No atopy Atopic dermatitis Allergic rhinitis Asthma Any atopic disease Gender .98* .42* .94* .55* Female 33 (32.7%) 68 (32.9%) 79 (28.4%) 58 (33.1%) 103 (29.6%) Male 68 (67.3%) 139 (67.1%) 199 (71.6%) 117 (66.9%) 245 (70.4%) Race .53* .79* .99* .85* White 87 (91.6%) 182 (89.2%) 244 (92.4%) 153 (91.6%) 307 (92.2%) Non-white 8 (8.4%) 22 (10.8%) 20 (7.6%) 14 (8.4%) 26 (7.8%) Age at EoE diagnosis, y 36.9 6 19.0 26.1 6 17.0 \.001 y 30.2 6 16.8 .001 y 26.0 6 16.4 \.001 y 28.7 6 16.7 \.001 y Family history of atopy 17 (16.8%) 121 (58.5%) \.001* 153 (55.0%) \.001* 97 (55.4%) \.001* 177 (50.9%) \.001* Peripheral eosinophils, k/L 0.38 [0.27,0.60] 0.53 [0.30, 0.80] .003 z 0.49 [0.28, 0.75] .021 z 0.56 [0.37, 0.90] \.001 z 0.49 [0.30, 0.76] .008 z Serum IgE, U/mL 36.5 [6.2, 383.1] 287.5 [65.7, 577.0] .014 z 238.5 [62.8, 611.0] .016 z 341.0 [73.9, 632.0] .009 z 198.5 [58.8, 574.1] .024 z Values presented as mean 6 SD; median [25th percentile, 75th percentile]; or N (%). P values: *Pearson  2 test; y t test; z Wilcoxon rank sum test. JAM ACAD DERMATOL MARCH 2017 560 Letters