RESEARCH ARTICLE Gurusamy Mariappan et al, Int.J.A.PS.BMS , Jan‐Mar.2013, Vol.2.(1) ,061‐067 ISSN‐2277‐9280 www.ijapsbs.com Hetero Group of Journal 61 “Angiogenesis inhibitors” targets for cancer treatment. Abstract Ten novel oxazolone derivatives 2a‐j were synthesized by microwave synthesizer by reacting 2‐furoyl glycine with substituted aromatic and hetero aromatic aldehyde in presence of sodium acetate and acetic anhydride. All these compounds were characterized by UV, IR, 1 HNMR, mass spectroscopy and elemental analysis. The synthesized compounds were screened for oral hypoglycemic activity by streptozotocin induced model in rats at 50 mg/kg b.w. From the results observed, it was found that almost all the compounds reduced blood glucose level in diabetic rats as compared with standard drug glibenclamide. Amongst all, the compound 2f exhibited more prominent antidiabetic activity (125.67 mg/dl).The results were statistically verified for its significance. KEY WORDS Oxazolone, hypoglycemic activity, anti‐inflammatory, antidepressant 1.Introduction Microwave induced organic reaction enhancement has emerged as a simple, clean, fast, efficient, economic, environment friendly and non‐traditional method for the synthesis of large number of organic molecules. 1‐2 Amongst those molecules, oxazole plays a very vital role in the manufacturing of various biologically active agents such as analgesic, anti‐ inflammatory 3 , anticancer 4 , antimicrobial 5 , anti diabetic and anti obesity agents 6‐9 . The onset of insulin in body causes an abnormal effect on glucose metabolism which is related to the development of Type II diabetes. India has today become the diabetic capital of the world with over 20 million diabetics and this number is set to increase to 57 million by 2025 10. Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycaemia in diabetes mellitus. Due to their side effects, search for a new class of compounds is essential to overcome these problems. After pioneering discovery of ciglitazone 11 , a new class of thiazolidinedione based compounds has been developed to treat diabetic patients that can reverse the insulin resistance in non insulin dependent diabetes mellitus (NIDDM). The undesirable side effect such as hepatotoxicity limits the use of thiazolidinone derivatives as safe drug candidates. In view of this, it was of considerable interest to synthesize the title compound with a hope to obtain potent biologically active oral hypoglycemic agents. The starting material furoyl glycine was prepared by the reaction of glycine and furoyl chloride in the presence of sodium hydroxide. It was then irradiated at 200 watts with substituted aromatic and hetero aromatic aldehyde in presence of acetic anhydride and glacial acetic acid to obtain oxazolones. The chemistry used to prepare these analogs is illustrated in scheme1. Their structures have been elucidated from UV‐Vis, IR, 1 H NMR, Mass spectral data and elemental analysis. 2.Experimental 2.1 Materials and methods All the chemicals were of synthetic grade and commercially procured from Qualigen, Mumbai. Microwave synthesizer (Catalyst) was used for microwave irradiated (MWI) synthesis. Melting points were determined in open capillary method and are uncorrected. IR spectra were recorded on FT‐IR8400S, Fourier Transform (Shimadzu) Infrared spectrophotometer using KBr disc method. The proton magnetic resonance spectra ( 1 H‐NMR) were recorded on Perkin MICROWAVEASSISTEDSYNTHESIS OF SOME NOVEL OXAZOLONE DERIVATIVES AS ORAL HYPOGLYCEMIC AGENTS Lipika Pandey, Rashmi Karki, Angila Theengh, Janmajoy Banerjee. Gurusamy Mariappan* Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E .Sikkim‐737 136, India E‐mail: gmariappanhpi@yahoo.co.in