Accepted Manuscript Anti-Tumour Treatment Impact of neoadjuvant single or dual HER2 inhibition and chemotherapy back- bone upon Pathological Complete Response in operable and locally advanced breast cancer: sensitivity analysis of randomized trials Emilio Bria, Luisa Carbognin, Jenny Furlanetto, Sara Pilotto, Maria Bonomi, Valentina Guarneri, Cecilia Vicentini, Matteo Brunelli, Rolando Nortilli, Francesca Pellini, Isabella Sperduti, Diana Giannarelli, Giovanni Paolo Pollini, Pierfranco Conte, Giampaolo Tortora PII: S0305-7372(14)00086-3 DOI: http://dx.doi.org/10.1016/j.ctrv.2014.05.001 Reference: YCTRV 1302 To appear in: Cancer Treatment Reviews Cancer Treatment Re- views Received Date: 26 February 2014 Revised Date: 4 May 2014 Accepted Date: 6 May 2014 Please cite this article as: Bria, E., Carbognin, L., Furlanetto, J., Pilotto, S., Bonomi, M., Guarneri, V., Vicentini, C., Brunelli, M., Nortilli, R., Pellini, F., Sperduti, I., Giannarelli, D., Pollini, G.P., Conte, P., Tortora, G., Impact of neoadjuvant single or dual HER2 inhibition and chemotherapy backbone upon Pathological Complete Response in operable and locally advanced breast cancer: sensitivity analysis of randomized trials, Cancer Treatment Reviews Cancer Treatment Reviews (2014), doi: http://dx.doi.org/10.1016/j.ctrv.2014.05.001 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.