www.sciedu.ca/jhm Journal of Hematological Malignancies, December 2011, Vol. 1, No. 1 Published by Sciedu Press 57 CASE REPORT F18 FDG PET uptake for the staging of Castleman disease and co-incidental uptake in lactating breast Semra Paydas, Gulgun Buyukdereli, Melek Ergin, Aygul Polat Kelle, Erkut Erkurt Cukurova University Facuty of Medicine Departments of Medical Oncology, Nuclear Medicine, Pathologyand Radiation Oncology. Correspondence: Semra Paydas. Address： Department of Oncology, Cukurova University faculty of Medicine, Adana, Turkey. Telephone: 90-322-3386-060. Email: sepay@cu.edu.tr Received: August 24, 2011 Accepted: October 17, 2011 Published: December 1, 2011 DOI : 10.5430/jhm.v1n1p57 URL: http://dx.doi.org/10.5430/jhm.v1n1p57 Abstract Castleman Disease (CD) is an interesting and relatively rare lymphoproliferative disorder. The managemet of this entity depends to the presence of one or more than one foci. FDG PET is a novel diagnostic method to detect the unicentricity or multicentricity of the tumor. Here PET findings of a case with CD have been reported and co-incidental lactating breast uptake has been presented. Key words Castleman disease, FDG uptake, Lactating breast Case report A 37 year-old-woman was admitted to the hospital with a diagnosis of Castleman Disease (CD). Diagnosis had been done in another center and biopsy sample was re-evaluated by our pathologist (ME). She had a history of a mass in her left cervical region since 2 years. After detailed evaluation, an inscisional biopsy had been taken from this mass and this had been reported as CD hyaline vascular type. She had no history of systemic symptoms including fever, night swetas and weight loss. There was no evidence of autoimmune phenomena including hemolytic anemia, ANA positivity, hyperglobulinemia and high CRP levels. Past medical history revealed a surgery for hypophyseal adenoma 4 years ago. She has a baby and breast feeding from her left breast only. She had the history of lactation from only left breast in all of her postpartum period. Physical examination showed a 4 cm × 6 cm × 9 cm hard, infiltrative mass in left cervical region. Other findings were unremarkable. Laboratory: Hb was 12.3g/dL, Hct was 37.4%, WBC count was 4.78 × 10 9 /L, platelet count was 258 × 10 9 /L, ESR was 16 mm/h. Biochemical tests were within normal limits, except low HDL. Biopsy findings of the mass was compatible with CD-hyaline vascular type and biopsy showed numerous atrophic germinal centers that were circumferentially rimmed by small lymphocytes, and that within some of the germinal centers, there were ill-defined blood vessels. There was an extensive capillary proliferation within the affected lymph nodes.