Administration of probiotic sanolife Mic-S on biological performance of Vanamei Shrimp (Litopenaeus vannamei) PL 10 Hasim 1 , Nadia Baidi 1 , Syamsuddin 1 , Rully Tuiyo 1 1 Department of Aquaculture, Faculty of Fisheries and Marine Sciences, State University of Gorontalo e-mail : hasim@ung.ac.id Abstract. Vannamei shrimp is a fishery commodity that has important economic value for Indonesia. This is indicated by the increasing number and value of exports of this commodity. One of the efforts to encourage the production of vaname shrimp is through the use of probiotics. sanolife-MIC is a probiotic widely used in shrimp culture. The aim of the study was to analyze the feed profile and biological performance of Vaname PL 10 shrimp fed pellets with the Sanolife MIC-S probiotic capsule at different doses. The research method used is an experimental method using a completely randomized design (CRD) with four treatments (A: probiotic 0 gr/kg feed; B: probiotic 10 gr/kg feed; C: probiotic 12 gr/kg feed; D: probiotic 14 g/kg feed) and three replicates. What was tested in the study were probiotic profile tests, growth, feed efficiency and feed conversion. The data obtained were analyzed using ANOVA. The results showed that the feed profile that was encapsulated using sanolife MIC-S, the protein value, moisture content and ash content for the feed were shown by treatment B. The best fat content was treatment C. The best crude fiber content was treatment D. Weight growth rate, ratio The best feed conversion and feed efficiency was shown by treatment B, while the length growth and survival was indicated by treatment C. Keywords: Vannamei Shrimp, Probiotics, Growth, and Survival. Introduction Vaname Shrimp (Litopenaeus vannamei) is a leading commodity in several countries in the world, including Indonesia. Therefore, Indonesia makes Vaname Shrimp as the main export commodity of the fisheries sector. Indonesia is even the 4th largest shrimp exporter in the world after India, Vietnam and Ecuador (FAO 2017). Vaname Shrimp cultivation is very developed because this species has advantages. Vannamei shrimp have high adaptability to environmental factors such as temperature and salinity. Then this type of shrimp has a good acceptance of commercial feed (Adiwijaya and Sumantri, 2008). The development of shrimp farming has pushed the need for commercial feed to increase. On the one hand, commercial feed is the largest component in aquaculture production costs, which can reach 60% (Heptarina et al. 2010). Feed is one of the main components in cultivation to obtain high growth and survival. However, feeding with high protein content has the potential to cause pollution. Because not all of the feed given is effectively consumed by the shrimp. On the other hand, only part of it is able to be assimilated by the shrimp body (Febrianti et al. 2010). Furthermore, the rest will be toxic compounds such as ammonia and 42 Technium Vol. 3, Issue 8 pp.42-57 (2021) ISSN: 2668-778X www.techniumscience.com