International Journal of Research in Medical Sciences | June 2016 | Vol 4 | Issue 6 Page 2024 International Journal of Research in Medical Sciences Choudhary PR et al. Int J Res Med Sci. 2016 Jun;4(6):2024-2029 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Research Article Study of thyroid function in patients with metabolic syndrome Prema Ram Choudhary*, Ramesh Chandra D. Jani INTRODUCTION The metabolic syndrome (syndrome X or insulin resistance syndrome) is one of the major public health issues of this century. It is a constellation of physical conditions and metabolic abnormalities which include central obesity, hyperglycemia plus insulin resistance (IR), hypertension, dyslipidemia and pro-inflammatory conditions, usually occurring together that increases an individual’s risk for development of type 2 diabetes mellitus and cardiovascular disease. 1 Thyroid has ubiquitous effects and influences the function of most organs. Thyroid hormones play an important role in regulating energy homeostasis, carbohydrate, lipids and protein metabolism. This hormone appears to serve as a general pacemaker accelerating metabolic processes and may be associated with metabolic syndrome. Hyperthyroidism is usually associated with low cholesterol and glucose intolerance; whereas hypothyroidism is associated with high cholesterol tendency, and patients are prone to weight gain and cardiac signs like bradycardia. 2 Thyroid functions affect the components of MetS including HDL–cholesterol (HDL-C), triglycerides (TG), blood pressure and plasma glucose. The impact of various degree of thyroid dysfunction (TD) on components of MetS, however, continues to be debatable. 3 These metabolic disorders associate with cardiovascular ABSTRACT Background: Thyroid disease and the metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to explore the study of thyroid function in patients with metabolic syndrome. Methods: This cross-sectional study was conducted at department of physiology, M P shah medical college Jamnagar, Gujarat. It included 200 patients with metabolic syndrome (MetS) (National Cholesterol Education Program’s-Adult Treatment Panel III Criteria) in the study group and 100 subjects without metabolic syndrome in the control group. Anthropometric variables and blood pressure were taken using standardized technique and body mass index was calculated. Fasting blood sample was analyzed for total cholesterol (TC), triglycerides (TG), high density lipoproteins cholesterol (HDL-C), blood glucose (FBG) and TSH, T 4 and T 3 were measured using electro- chemiluminescence immuno assay. Statistical analysis was performed using SPSS windows version 20.0 software (SPSS Inc., Chicago, Illinois). Results: The overall prevalence of thyroid dysfunction in patients with MetS was 41.5% with high prevalence of sub clinical hypothyroidism (27%). TSH (P<0.001) was significantly higher in the study group than in control group (P <0.01) but T 3 and T 4 values of study group were significantly lower than those of control group (P< 0.01). Metabolic components waist circumference, blood pressure, fasting blood glucose and triglycerides were significantly higher in metabolic subject (P<0.001), while HDL-C was significantly lower in study group (P<0.001) then control group. Conclusion: Hypothyroidism brawny associated with components of metabolic syndrome, therefore increased multifaceted risk of cardiovascular disorders with elevate TSH levels. Key words: Metabolic syndrome, Thyroid stimulating hormone, Hypothyroidism, Central obesity Department of Physiology, C.U. Shah Medical College, Surendranagar, Gujarat, India Received: 22 March 2016 Accepted: 22 April 2016 *Correspondence: Dr. Prema Ram Choudhary, E-mail: prema5252@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161754