Jemds.com Original Research Article J. Evolution Med. Dent. Sci./eISSN- 2278-4802, pISSN- 2278-4748/ Vol. 9/ Issue 23/ June 08, 2020 Page 1782 HLA- A & B Association in Psoriasis in Tamil Speaking South Indian Population Ashwin Anandan 1 , Ravindraprasad Thokala 2 , Krishnamoorthy Radhakrishnan 3 , Vinod Kumar Panicker 4 , Murugan Sundaram 5 1 Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamilnadu, India. 2 Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamilnadu, India. 3 Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamilnadu, India. 4 Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamilnadu, India. 5 Department of Dermatology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamilnadu, India. ABSTRACT BACKGROUND Psoriasis is an auto-immune skin disease affecting skin, nails and joints. The association of HLA with psoriasis is already established with HLA- C*06 known to be associated strongly with the disease. We wanted to determine the HLA -A & HLA-B pattern and its association with psoriasis in a Tamil speaking ethnic population. METHODS A total of 100 psoriasis patients attending the Dermatology OPD at SRMC were taken up for the study. This was a case control study and hence 100 voluntary blood donors donating at the SRMC Hospital blood bank were taken up for study as controls. Voluntary blood donors are considered as healthy normal individuals and hence chosen as controls. All the 100 patients and 100 controls were typed for HLA (Human Leucocyte Antigen) - A & B by PCR-SSP (Polymerase Chain Reaction-Sequence Specific Primers) and the results were analysed statistically using OpenEpi software (2 X 2 table). The Odds Ratio (OR), p (probability) value, and 95% confidence interval were the statistical tests which were studied. RESULTS HLA-A*02, 24 and HLA-B*35 were found to be strongly associated with psoriasis among Tamil speaking ethnic population. CONCLUSIONS There are different HLA – A & B alleles associated with psoriasis in Tamil ethnic population in comparison with other ethnic studies. KEY WORDS Human Leucocyte Antigen, Polymerase Chain Reaction–Sequence Specific Primers, psoriasis, Odds Ratio, Alleles, Tamil Ethnicity Corresponding Author: Dr. Ravindraprasad Thokala, Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Porur, Chennai-600116, Tamilnadu, India. E-mail: drravi1212@gmail.com DOI: 10.14260/jemds/2020/390 Financial or Other Competing Interests: None. How to Cite This Article: Anandan A, Thokala R, Radhakrishnan K, et al. HLA- A & B association in psoriasis in tamil speaking South Indian population. J. Evolution Med. Dent. Sci. 2020;9(23): 1782- 1786, DOI: 10.14260/jemds/2020/390 Submission 18-02-2020, Peer Review 25-03-2020, Acceptance 27-03-2020, Published 08-06-2020.