Sulemanjee NZ| Volume 2; Issue 3 (2021) | Mapsci-JCCR-2(3)-033 | Research Article Citation: Sulemanjee NZ, Walczak S, Perez Moreno AC, Oldridge NB. Validation of the HeartQoL Health-Related Qualityof Life Questionnaire in Patients with Chronic Ischemic Cardiomyopathy. J Cardiol Cardiovasc Res. 2021;2(3):16. DOI: https://doi.org/10.37191/Mapsci-JCCR-2(3)-033 Journal of Cardiology and Cardiovascular Research Sulemanjee NZ, et al, 2021- J Cardiol Cardiovasc Res Research Article Validation of the HeartQoL Health Related Quality of Life Questionnaire in Patients with Chronic Ischemic Cardiomyopathy Nasir Z Sulemanjee 1 *, Sara Walczak 2 , Ana Cristina Perez Moreno 3 and Neil B Oldridge 4 Abstract Objective: The English HeartQoL health-related quality of life questionnaire has been validated in patients with angina and myocardial infarction living in the USA but not in patients with symptomatic heart failure. The factor structure, reliability, validity and responsiveness of the English HeartQoL was assessed in patients with heart failure due to chronic ischemic cardiomyopathy. Methods: A battery of five questionnaires, including the HeartQoL with a Global scale and Physical and Emotional subscales, was self- administered by 90 patients with chronic ischemic cardiomyopathy in Wisconsin, USA, and the HeartQoL factor structure, reliability and validity were assessed. Responsiveness was examined in a separate cohort of 20 patients undergoing cardiac resynchronization therapy. Results: The 2-factor HeartQoL structure was confirmed. Internal consistency reliability was strong with Cronbach’s α ≥0.88. Convergent validity correlations between similar HeartQoL and Minnesota Living with Heart Failure questionnaire (r=-0.81 to - 0.82) and Short Form 36 Health Survey constructs (r=0.74 to 0.78) were strong with significantly weaker correlations between dissimilar constructs. Discriminative validity was confirmed on 1 Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke’s Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway, Suite 880, Milwaukee, Wisconsin, USA 2 Advocate Aurora Research, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Suite 880, Milwaukee, Wisconsin, USA 3 Cardiovascular Research, Advocate Aurora Research, Advocate Aurora Health, Milwaukee, Wisconsin, USA 4 College of Health Sciences, University of Wisconsin-Milwaukee, 6975 N. Elm Tree Road, Glendale, Wisconsin, USA * Corresponding Author: Nasir Z. Sulemanjee, MD, FACC, FHFSA, Aurora St. Luke’s Medical Center, 2801 W. Kinnickinnic River Parkway, Suite #130, Milwaukee, WI 53215, USA. Accepted Date: 07-31-2021 Published Date: 08-31-2021 Copyright© 2021 by Sulemanjee NZ, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.