Samanta et al Journal of Drug Delivery & Therapeutics. 2020; 10(2-s):27-29 ISSN: 2250-1177 [27] CODEN (USA): JDDTAO Available online on 15.04.2020 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Research Article The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources Radheshyam Samanta 1 *, Asish Bhaumik 2 , Dr. Amit Kumar Nayak 3 1 Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India 2 Associate Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-821305, Sasaram, Bihar, India 3 Associate Professor, Department of Pharmaceutics, Seemanta Institute of pharmaceutical Sciences, Jharpokharia, Mayurbhang-757086, Odisha, India. ABSTRACT The main aim and objective of my present research work was to determine the various important mucoadhesive parameters such as mucoadhesive force, force of adhesion and bonding strength etc. Mucoadhesive properties of natural polymers were evaluated by formulating gels using Carbopol 940 P as a gelling agent. Mucoadhesive parameters of the prepared Carbopol 940 P gels containing natural polymers were determined by ex vivo followed by modified physical balance using excised cock intestinal mucosa. From the recent experimental data it was displayed that the mucoadhesive strength, force of adhesion and bonding strength of gel containing low methoxy pectin (1 % w/v) was found higher than other tested gels. The gel containing Moringa oleifera gum (1 % w/v) exhibited less mucoadhesion than other tested gels. The order of mucoadhesion of these plant-derived polymers was found as: low methoxy pectin > jackfruit seed starch > cashew gum/okra gum gum > pumpkin pectin > linseed mucilage > sago starch > gum Arabic > xanthan gum > fenugreek seed mucilage/black palm seed polysaccharide > Moringa oleifera gum. Keywords: Mucoadhesion, Mucoadhesive strength, gelling agent, intestinal mucosa, and plant derived polymers etc. Article Info: Received 24 Jan 2020; Review Completed 18 March 2020; Accepted 26 March 2020; Available online 15 April 2020 Cite this article as: Samanta R, Bhaumik A, Nayak AK, The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources, Journal of Drug Delivery and Therapeutics. 2020; 10(2-s):27-29 http://dx.doi.org/10.22270/jddt.v10i2-s.3952 *Address for Correspondence: Radheshyam Samanta, Assistant Professor, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar- 821305, Sasaram, Bihar, India INTRODUCTION Mucoadhesion is defined as the attachment of synthetic or natural macromolecules to any mucus-lining present on biological epithelial surface [1]. It is mostly achieved by the use of mucoadhesive polymers [2-4]. Mucoadhesion is provided by the formation of non-covalent bonds such as hydrogen bonds and ionic interactions or physical entanglements between the mucus gel layer and polymers. Classification of mucoadhesive polymers The classification of various mucoadhesive polymers used in the formulation of various mucoadhesive systems is [1-5]: (I) Synthetic polymers: (a) Cellulose derivatives: Methylcellulose, Ethylcellulose, Hydroxy-ethylcellulose, Hydroxyl propyl cellulose, Hydroxy propyl methylcellulose, Sodium carboxy methylcellulose. (b) Poly (acrylic acid) polymers: Carbomers, olycarbophil. (c) Poly (hydroxyethyl methylacrylate). (d) Poly (vinyl alcohol), etc. (II) Natural polymers: (a) Sodium alginate. (b) Guar gum. (c) Xanthan gum. (d ) Lectin. (e) Gelatin. (f) Pectin. (g) Chitosan etc. Natural mucoadhesive polymers obtained from plant sources The use of natural polymers in various biomedical and food continues to be an area of intensive research despite the advent of several new synthetic polymers [6]. Natural polymers primarily remain attractive for their capability of chemical modifications, biodegradability and biocompatibility [7-8]. Various conventional natural mucoadhesive polymers like guar gum, chitosan, xanthane gum, alginates, locust bean gum, alginate, etc, were already well studied and investigated in various drug delivery applications [6, 9-12]. In the literature, there are several reports on natural mucoadhesive agents, which were isolated from various plant materials and have found their use for the development