_____________________________________________________________________________________________________ *Corresponding author: E-mail: samyzekilah@yahoo.co.uk; Journal of Advances in Medicine and Medical Research 32(24): 229-237, 2020; Article no.JAMMR.64788 ISSN: 2456-8899 (Past name: British Journal of Medicine and Medical Research, Past ISSN: 2231-0614, NLM ID: 101570965) Role of Hybrid Interventions in Management of Critical Lower Limb Ischemia Samy R. Zekilah 1* , Adel H. Kamhawy 1 , Hassan A. Hassan 1 , Mohamed A. El-heniedy 1 and Ahmed M. Ismael 1 1 Department of Vascular Surgery, Faculty of Medicine, Tanta University, Tanta, Egypt. Authors’ contributions This work was carried out in collaboration among all authors. Author SRZ designed the study, performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Authors AHK and HAH managed the analyses of the study and supervised the operative interventions. Author MAEH managed the literature searches. Author AMI managed the linguistic integrity and final arrangement. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMMR/2020/v32i2430772 Editor(s): (1) Dr. Sandra Aparecida Marinho, Paraíba State University (Universidade Estadual da Paraíba - UEPB), Brazil. Reviewers: (1) Mehmet Işık, Necmettin Erbakan University, Turkey. (2) Krishna Kumar G., Jawaharlal Institute of Postgraduate Medical Education and Research, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/64788 Received 25 October 2020 Accepted 30 December 2020 Published 31 December 2020 ABSTRACT Aims: To evaluate safety and efficacy of the hybrid technique in revascularization of multilevel lower limb arterial occlusive disease in patients with critical lower limb ischemia. Study Design: A prospective non comparative interventional study. Place and Duration of Study: It was conducted between February 2017 and June 2019 in the Department of Vascular Surgery, Tanta University hospital. Methodology: The study included 23 patients were treated with hybrid intervention techniques, and data were collected prospectively. Detailed history was taken and clinical examination was done for every patient along with routine laboratory investigations and radiological work up like duplex scanning with or without CT angiography. All patients were undergone hybrid interventions in an operating room with imaging facilities (mobile c-arm device) where both surgical and endovascular interventions were done simultaneously. Results: Twenty three patients were treated for unilateral critical lower limb ischemia using single session elective hybrid intervention. The patients age ranged from 46 to 76 (mean 62.6) with 19 Original Research Article