Khurana et al Journal of Drug Delivery & Therapeutics. 2018; 8(5-s):1-11 ISSN: 2250-1177 [1] CODEN (USA): JDDTAO Available online on 15.10.2018 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Review Article TOPICAL DELIVERY OF NANOEMULSION FOR ANTIPSORIATIC DRUGS Bharat Khurana 1, 2 *, Daisy Arora 1, 3 & R.K. Narang 1 1 Nanomedicine Research Centre, Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab) India 2 Department of Pharmacy, Maharaja Ranjit Singh Punjab Technical University, Bathinda, (Punjab) India 3 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, (Haryana) India ABSTRACT Psoriasis is an autoimmune disorder of the skin characterized by relapsing episodes of inflammatory lesions and hyperkeratotic plaques with worldwide occurrence of around 2–5%. Psoriasis is a disease known to be caused by multitude of both genetic and environmental factors such as trauma, drugs, infection, alcohol, smoking and stress but its accurate origin is still not known. Further, available treatment options are associated with both inappropriate cosmetic appearance and related toxicities leading to poor patient compliance in long term use. Nanotechnology based drug delivery system has immense potential to enhance the bioavailability and effectiveness of drugs in their dosage forms, especially lipophilic drugs. Lipid based carrier system can overcome the lipid imbalance and normal moisturizing factors. Nanoemulsions, as one of a new carrier apparently have the prospective to conquer numerous problems related with topical antipsoriatic therapy. This delivery system could perhaps offer a good alternative in topical psoriasis treatment. Not only on how nanoemulsions prepared, but it depends on the active ingredients used and the selection of oil could as well enhance the efficiency of topical treatment towards psoriasis. A good combination of both active and suitable oils would result a better treatment and better effect. Keywords: Topical nanoemulsion, Antipsoriatic therapy, Critical quality attributes. Article Info: Received 23 July, 2018; Review Completed 11 Sep 2018; Accepted 13 Sep 2018; Available online 15 Oct 2018 Cite this article as: Khurana B, Arora D, Narang RK, Topical delivery of nanoemulsion for antipsoriatic drugs, Journal of Drug Delivery and Therapeutics. 2018; 8(5-s):1-11 DOI: http://dx.doi.org/10.22270/jddt.v8i5-s.1914 *Address for Correspondence: Bharat Khurana, Nanomedicine Research Centre, Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab) India 1. INTRODUCTION OF PSORIASIS Psoriasis is an autoimmune disorder of the skin characterized by relapsing episodes of inflammatory lesions and hyperkeratotic plaques with worldwide occurrence of around 2–5% The psoriasis can be classified on the basis of extent of inflammatory process, localization of rash, severity of the patient condition, and other clinical traits into chronic plaque, guttate, pustular, erythroderma, Scalp, nail, facial, flexural psoriasis and Psoriatic arthritis as shown in table 1. Amongst these, chronic plaque psoriasis (CPP) represents major occurrence proportion with equivalent likelihood in both sexes and early onset before the age of 40 years. 1