_____________________________________________________________________________________________________ *Corresponding author: E-mail: mmehrabani@hotmail.com; Journal of Pharmaceutical Research International 27(2): 1-11, 2019; Article no.JPRI.48217 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Development of an Efficient Extraction Method for Separating Solasodine, an Steroidal Alkaloid, From an Oily Matrix: A Comparison Between LLE and SPE Shahram Kalantari Khandani 1,2 , Mitra Mehrabani 1* , Fariba Sharififar 1 , Abbas Pardakhty 3 and Mostafa Pournamdari 4 1 Department of Pharmacognosy, Herbal and Traditional Medicines Research Center, Faculty of Pharmacy Kerman University of Medical Sciences, Kerman, Iran. 2 Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran. 3 Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. 4 Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran. Authors’ contributions This work was carried out in collaboration among all authors. Authors MM and SKK designed the study and wrote the protocol. Authors SKK, MP and FS managed the analyses of the study, performed the statistical analysis and wrote the first draft of the manuscript. Authors FS and AP managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2019/v27i230163 Editor(s): (1) R. Deveswaran, M. Pharm., Ph.D., Associate Professor & Head-Drug Design and Development Centre, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bangalore-560054, India. Reviewers: (1) R. Sathiyasundar, DR. MGR Medical University, India. (2) Hideharu Shintani, Chuo University, Japan. Complete Peer review History: http://www.sdiarticle3.com/review-history/48217 Received 27 January 2019 Accepted 23 April 2019 Published 07 May 2019 ABSTRACT Aims: In many references of Traditional Iranian Medicine (TIM), there are methods to produce medicinal products from plant fruit based on extraction of active substances into oils. One of these recommendations is to import cucurbit or pumpkin seed oil into an entirely ripe fruit of Solanum melongena plant. In this study for the first time, the extraction of solasodine from the oily matrix has been investigated to find a precise method with suitable extraction recovery. Original Research Article